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The Dissemination of NDM-1 in Acinetobacter baumannii Strains

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Abstract

Acinetobacter baumannii is a common pathogen in hospitals and usually causes bacteremia, pneumonia, meningitis, peritonitis and other diseases. Isolates carried NDM-1 gene can make several antibiotics such as carbapenems and other beta-lactams ineffective. Nowadays, the number of A. baumannii strains carrying NDM-1 has been climbing year by year in recent years. To characterise the transmission of NDM-1 in A. baumannii, we collected 2576 human-derived genomes of A. baumannii strains from NCBI database and found that 186 strains contained NDM-1 gene. The multi-locus sequence typing, phylogenetic tree, NDM-1 gene organization and the single nucleotide polymorphisms of NDM-1 were investigated. We hope that our work will provide a theoretical basis for the prevention of dissemination of NDM-1 in A. baumannii.

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Data Availability

The datasets analyses during the current study are available in the NCBI database.

Code Availability

Not applicable.

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Acknowledgements

We thank for the helps of all the members of Songnian Hu group in Institute of Microbiology, Chinese Academy of Sciences, China.

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Author notes

  1. Na Liu and Xin Zheng have contributed equally to this work.

Authors and Affiliations

  1. Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University, Beijing, 100191, People’s Republic of China

    Na Liu & Zilong He

  2. State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China

    Xin Zheng, Qianhui Zhu & Songnian Hu

  3. University of Chinese Academy of Sciences, Beijing, 100049, China

    Xin Zheng, Qianhui Zhu & Songnian Hu

  4. School of Engineering Medicine, Beihang University, 37 Xueyuan Road, Haidian District, Beijing, 100191, People’s Republic of China

    Na Liu & Zilong He

Authors
  1. Na Liu
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  2. Xin Zheng
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  3. Qianhui Zhu
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  4. Zilong He
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  5. Songnian Hu
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Contributions

NL, XZ: conducted sequencing data interpretation and analysis. SH and ZH: conceived and designed the experiments. NL, XZ, QZ: contributed to the manuscript preparation.

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Correspondence to Zilong He or Songnian Hu.

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All data in this paper are taken from public database without ethical conflict.

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Liu, N., Zheng, X., Zhu, Q. et al. The Dissemination of NDM-1 in Acinetobacter baumannii Strains. Curr Microbiol 79, 117 (2022). https://doi.org/10.1007/s00284-022-02812-w

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