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Current Microbiology

, Volume 75, Issue 5, pp 557–564 | Cite as

Lifespan Extension of Caenorhabditis elegans by Butyricicoccus pullicaecorum and Megasphaera elsdenii with Probiotic Potential

  • Gayeung Kwon
  • Jiyun Lee
  • Jong-Ho Koh
  • Young-Hee Lim
Article

Abstract

Butyricicoccus pullicaecorum and Megasphaera elsdenii inhabit the human intestine and have probiotic potential. The aim of this study was to evaluate the effects of B. pullicaecorum and M. elsdenii on the lifespan of Caenorhabditis elegans. They significantly (P < 0.05) extended the lifespan of C. elegans compared with Escherichia coli OP50, a standard food for the worm. Analysis of age-related biomarkers such as lipofuscin, body size, and locomotory activity showed that they retarded aging. They all failed to extend the lifespan of daf-12 or dbl-1 loss-of-function C. elegans mutants compared with E. coli OP50-fed worms. However, the increase in lifespan was observed in daf-16, jnk-1, pmk-1, and skn-1 mutants. Moreover, they increased the resistance of C. elegans to a human pathogen, Salmonella typhimurium. In conclusion, B. pullicaecorum and M. elsdenii extend the lifespan of C. elegans via the transforming growth factor-beta (TGF-β) pathway associated with anti-inflammatory processes in the innate immune system.

Notes

Acknowledgements

This study was supported by Korea University Grant (K1711191).

Compliance with Ethical Standards

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2017

Authors and Affiliations

  • Gayeung Kwon
    • 1
  • Jiyun Lee
    • 1
  • Jong-Ho Koh
    • 2
  • Young-Hee Lim
    • 1
    • 3
    • 4
  1. 1.Department of Public Health Science (Brain Korea 21 PLUS Program), Graduate SchoolKorea UniversitySeoulRepublic of Korea
  2. 2.Department of Bio-Food Analysis and ProcessingBio-Campus Korea Polytechnic CollegeNonsanRepublic of Korea
  3. 3.School of Biosystem and Biomedical Science, College of Health ScienceKorea UniversitySeoulRepublic of Korea
  4. 4.Department of Laboratory Medicine, Guro HospitalKorea UniversitySeoulRepublic of Korea

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