Abstract
The signal recognition particle (SRP) and its receptor constitute universally conserved and essential cellular machinery that controls the proper membrane localization of nascent polypeptides with the transmembrane domain. In the past decade, there has been an immense advancement in our understanding of this targeting machine in all three domains of life. A significant portion of such progress came from the structural analysis of archaeal SRP components. Despite the availability of structural insights from different archaeal SRP components, little is known about protein translocation in this domain of life compared to either bacteria or eukaryotes. One of the primary reasons being limited availability of the genetic and cell biological tools in archaea. In the present review, an attempt has been made to explore the structural information available for archaeal SRP components to gain insights into the protein translocation mechanism of this group of organisms. Besides, many exciting avenues of archaeal research possible using the recently developed genetic and cell biological tools for some species have been identified.
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Acknowledgements
The authors would like to thank the SERB (Science and Engineering Research Board), Department of Science and Technology (DST), New Delhi, India for providing Ramanujan Fellowship (SR/S2/RJN-106/2012) to AG. SG is supported by Council of Scientific and Industrial Research (CSIR), Government of India, and MR is supported by a fellowship from UGC (University Grant Commission), Government of India [Ref. No. 22/06/2014(i)EU-V dtd. 04.12.2014]. The authors wish to thank the anonymous reviewers for their valuable comments.
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Gupta, S., Roy, M. & Ghosh, A. The Archaeal Signal Recognition Particle: Present Understanding and Future Perspective. Curr Microbiol 74, 284–297 (2017). https://doi.org/10.1007/s00284-016-1167-9
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DOI: https://doi.org/10.1007/s00284-016-1167-9