Abstract
This study investigated the effects of KLDS 1.8701 and AD1 administrations by gavage on intestinal microflora and mucosal immunity in diarrhea mice infected by Escherichia coli O157:H7 compared to normal mice. The levels of E. coli, Enterobacteria, and Enterococcus decreased significantly (P < 0.05), while viable counts of Lactobacilli and Bifidobacterium increased in diarrhea mice. Moreover, KLDS 1.8701 and AD1 improved secretion of secretory immunoglobulin A and enhanced the levels of interferon-γ and interleukin. Results indicate that KLDS 1.8701 and AD1 could effectively alleviate diarrhea in mice via modulation of intestinal microflora and improve the function of immune system. The study on the effect of KLDS1.8701 and AD1 supplementation in human flora-associated animal models was recommended.
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This study was funded by 863 program of China:characteristic resources base of Lactic acid bacteria and research on lactic acid bacteria starter and metabolic engineering technology (2011AA100902) and Synergetic Innovation Center of Food Safety and Nutrition. The authors are also grateful for the financial support of the Ministry of Education, China.
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All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.
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Bian, X., Wang, Tt., Xu, M. et al. Effect of Lactobacillus Strains on Intestinal Microflora and Mucosa Immunity in Escherichia coli O157:H7-Induced Diarrhea in Mice. Curr Microbiol 73, 65–70 (2016). https://doi.org/10.1007/s00284-016-1010-3
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DOI: https://doi.org/10.1007/s00284-016-1010-3