Abstract
The biosynthesis of integric acid, a secondary metabolite of the wood-decay fungus Xylaria feejeensis strain 2FB-PPM08M, has been studied. Labeling experiments using [1-13C], [2-13C] and [1,2-13C2] acetate and l-methionine (methyl-13C) were separately performed with fungal culture. The labeling patterns of these metabolites indicated the same origin, and determined that integric acid was formed through the condensation of a sesquiterpene and a polyketide. These experiments showed that side chain of compounds would be synthesized by the polyketide pathway, while the ring carbon indicated the biosynthesis of compounds via the mevalonate pathway.
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We would like to thank the Global COE Program (Tottori University, Japan) on Advanced Utilization of Fungus/Mushroom Resources for Sustainable Society in Harmony with Nature for their valuable support and analytical processes.
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Srisapoomi, T., Ichiyanagi, T., Nakajima, H. et al. Biosynthesis of Integric Acid Isolated from the Wood-Decay Fungus Xylaria feejeensis 2FB-PPM08M. Curr Microbiol 70, 550–555 (2015). https://doi.org/10.1007/s00284-014-0759-5
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DOI: https://doi.org/10.1007/s00284-014-0759-5