Antibiofilm Activity of Zinc-Carbonate Hydroxyapatite Nanocrystals Against Streptococcus mutans and Mitis Group Streptococci

This is a preview of subscription content, access via your institution.

Fig. 1


  1. 1.

    Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43:5721–5732

    PubMed  Article  Google Scholar 

  2. 2.

    Clinical and Laboratory Standards Institute (2009) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 8th ed Approved standard M7-A8. Clinical and Laboratory Standards Institute, Wayne

  3. 3.

    Hannig C, Basche S, Burghardt T, Al-Ahmad A, Hannig M (2012) Influence of a mouthwash containing hydroxyapatite microclusters on bacterial adherence in situ. Clin Oral Investig. doi:10.1007/s00784-012-0781-6

    Google Scholar 

  4. 4.

    Jakubovics NS (2010) Talk of the town: interspecies communication in oral biofilms. Mol Oral Microbiol 25:4–14

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Lamont RJ, Rosan B (1990) Adherence of mutans streptococci to other oral bacteria. Infect Immun 58:1738–1743

    PubMed  CAS  Google Scholar 

  6. 6.

    Marsh PD, Moter A, Devine DA (2011) Dental plaque biofilms: communities, conflict and control. Periodontol 2000 55:16–35

    PubMed  Article  Google Scholar 

  7. 7.

    Nobbs AH, Lamont RJ, Jenkinson HF (2009) Streptococcus adherence and colonization. Microbiol Mol Biol Rev 73:407–450

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Orsini G, Procaccini M, Manzoli L, Giuliodori F, Lorenzini A, Putignano A (2010) A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice. J Clin Periodontol 37:510–517

    PubMed  Article  Google Scholar 

  9. 9.

    Periasamy S, Kolenbrander PE (2009) Mutualistic biofilm communities develop with Porphyromonas gingivalis and initial, early, and late colonizers of enamel. J Bacteriol 191:6804–6811

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K (2007) Relationship between periodontal infections and systemic disease. Clin Microbiol Infect S4:3–10

    Article  Google Scholar 

  11. 11.

    Stauder M, Papetti A, Daglia M, Vezzulli L, Gazzani G, Varaldo PE, Pruzzo C (2010) Inhibitory activity by barley coffee components towards Streptococcus mutans biofilm. Curr Microbiol 61:417–421

    PubMed  Article  CAS  Google Scholar 

  12. 12.

    Whitmore SE, Lamont RJ (2011) The pathogenic persona of community-associated oral streptococci. Mol Microbiol 81:305–314

    PubMed  Article  CAS  Google Scholar 

Download references


Coswell S.P.A. provided the materials and partial support for the study, but had no role in planning, conduction, data analysis or any phase of the study.

Conflict of interest

All authors declare that they have no conflict of interest.

Author information



Corresponding author

Correspondence to Bruna Facinelli.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Palmieri, C., Magi, G., Orsini, G. et al. Antibiofilm Activity of Zinc-Carbonate Hydroxyapatite Nanocrystals Against Streptococcus mutans and Mitis Group Streptococci. Curr Microbiol 67, 679–681 (2013).

Download citation


  • American Type Culture Collection
  • Dental Plaque
  • Clinical Laboratory Standard Institute
  • Antibiofilm Activity
  • Aggregatibacter Actinomycetemcomitans