Antibiofilm Activity of Zinc-Carbonate Hydroxyapatite Nanocrystals Against Streptococcus mutans and Mitis Group Streptococci
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Dental plaque is a complex multispecies biofilm consisting of a dense community of interacting bacteria (~1010 cells/mg) embedded in a self-produced polysaccharide matrix [1, 4]. Plaque control is critical for oral health, since plaque bacteria include pathogens involved in both dental caries and periodontal disease—the most prevalent human microbial diseases—in addition to a variety of opportunistic pathogens that cause endocarditis, bacteraemia and septicaemia .
Plaque formation follows a regimented pattern of colonisation steps that begin with specific adhesion of pioneer colonizers to the acquired pellicle on the tooth surface followed by adhesion of secondary colonizers through interbacterial coaggregation . Streptococcus mitis, Streptococcus gordonii, Streptococcus oralis and Streptococcus sanguinis,all mitis group streptococci (MGS), are dominant pioneer species capable of irreversible attachment to the acquired pellicle by stereochemical interactions between bacterial...
KeywordsAmerican Type Culture Collection Dental Plaque Clinical Laboratory Standard Institute Antibiofilm Activity Aggregatibacter Actinomycetemcomitans
Coswell S.P.A. provided the materials and partial support for the study, but had no role in planning, conduction, data analysis or any phase of the study.
Conflict of interest
All authors declare that they have no conflict of interest.
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