Current Microbiology

, Volume 67, Issue 6, pp 679–681 | Cite as

Antibiofilm Activity of Zinc-Carbonate Hydroxyapatite Nanocrystals Against Streptococcus mutans and Mitis Group Streptococci

  • Claudio Palmieri
  • Gloria Magi
  • Giovanna Orsini
  • Angelo Putignano
  • Bruna FacinelliEmail author

Dental plaque is a complex multispecies biofilm consisting of a dense community of interacting bacteria (~1010 cells/mg) embedded in a self-produced polysaccharide matrix [1, 4]. Plaque control is critical for oral health, since plaque bacteria include pathogens involved in both dental caries and periodontal disease—the most prevalent human microbial diseases—in addition to a variety of opportunistic pathogens that cause endocarditis, bacteraemia and septicaemia [10].

Plaque formation follows a regimented pattern of colonisation steps that begin with specific adhesion of pioneer colonizers to the acquired pellicle on the tooth surface followed by adhesion of secondary colonizers through interbacterial coaggregation [6]. Streptococcus mitis, Streptococcus gordonii, Streptococcus oralis and Streptococcus sanguinis,all mitis group streptococci (MGS), are dominant pioneer species capable of irreversible attachment to the acquired pellicle by stereochemical interactions between bacterial...


American Type Culture Collection Dental Plaque Clinical Laboratory Standard Institute Antibiofilm Activity Aggregatibacter Actinomycetemcomitans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Coswell S.P.A. provided the materials and partial support for the study, but had no role in planning, conduction, data analysis or any phase of the study.

Conflict of interest

All authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Claudio Palmieri
    • 1
  • Gloria Magi
    • 1
  • Giovanna Orsini
    • 2
  • Angelo Putignano
    • 2
  • Bruna Facinelli
    • 1
    Email author
  1. 1.Section of Microbiology, Department of Biomedical Sciences and Public HealthPolytechnic University of MarcheAnconaItaly
  2. 2.Department of Clinical Sciences and StomatologyPolytechnic University of MarcheAnconaItaly

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