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Effect of a Probiotic Intake on Oxidant and Antioxidant Parameters in Plasma of Athletes During Intense Exercise Training

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Abstract

The aim of this study was to evaluate the effect of Lactobacillus rhamnosus IMC 501® and Lactobacillus paracasei IMC 502® on oxidative stress in athletes during a four-week period of intense physical activity. Two groups of twelve subjects each were selected for this analysis. The first group consumed a daily dose of a mixture of the two probiotic strains (1:1 L. rhamnosus IMC 501® and L. paracasei IMC 502®; ~109 cells/day) for 4 weeks. The second group (control) did not consume any supplements during the 4 weeks. Blood samples collected immediately before and after the supplementation were analyzed, and plasma levels of reactive oxygen metabolites and biological antioxidant potential were determined. Faeces were also collected and analyzed before and at the end of the probiotic supplementation. Antioxidative activity and oxidative stress resistance of the two strains were determined in vitro. Results demonstrated that intense physical activity induced oxidative stress and that probiotic supplementation increased plasma antioxidant levels, thus neutralizing reactive oxygen species. The two strains, L. rhamnosus IMC 501® and L. paracasei IMC 502®, exert strong antioxidant activity. Athletes and all those exposed to oxidative stress may benefit from the ability of these probiotics to increase antioxidant levels and neutralize the effects of reactive oxygen species.

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Acknowledgment

This study was supported by the School of Pharmacy, Unit of Experimental Medicine and Public Health, the School of Pharmacy, Hygiene and Public Health Research Centre and the School of Biosciences and Biotechnology, University of Camerino.

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Authors and Affiliations

  1. School of Pharmacy, Unit of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle carceri 9, 62032, Camerino, MC, Italy

    Daniele Martarelli & Pierluigi Pompei

  2. School of Biosciences and Biotechnologies, University of Camerino, 62032, Camerino, MC, Italy

    Maria Cristina Verdenelli, Stefania Silvi & Cinzia Cecchini

  3. School of Pharmacy, Hygiene and Public Health Research Centre, University of Camerino, 62032, Camerino, MC, Italy

    Stefania Scuri & Mario Cocchioni

Authors
  1. Daniele Martarelli
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  2. Maria Cristina Verdenelli
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  3. Stefania Scuri
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  4. Mario Cocchioni
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  5. Stefania Silvi
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  6. Cinzia Cecchini
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  7. Pierluigi Pompei
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Corresponding author

Correspondence to Daniele Martarelli.

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Daniele Martarelli and Maria Cristina Verdenelli contributed equally to this study.

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Martarelli, D., Verdenelli, M.C., Scuri, S. et al. Effect of a Probiotic Intake on Oxidant and Antioxidant Parameters in Plasma of Athletes During Intense Exercise Training. Curr Microbiol 62, 1689–1696 (2011). https://doi.org/10.1007/s00284-011-9915-3

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  • DOI: https://doi.org/10.1007/s00284-011-9915-3

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