Abstract
In a 39-year-old patient under follow-up for metastatic adenocarcinoma of the colon, a post-operative fever and a profound neutropenia occurred during hospitalization. A diagnosis of primary infection with parvovirus B-19 was made in view of the association of reticulocytopenia, together with anti-B19 IgM antibodies and positive serum results for viral DNA. The granulocytic lineage appeared to be normal on bone-marrow smears, and anti PMN autoantibodies were not found. Rh G-CSF therapy resulted in a sharp increase in the PMN count. Although the pathophysiology of B19-associated neutropenia remains unclear, Rh G-CSF seems to be effective in this disorder.
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Gautier, E., Bourhis, J.H., Bayle, C. et al. Parvovirus B19 associated neutropenia. Treatment with Rh G-CSF. Hematol Cell Ther 39, 85–87 (1997). https://doi.org/10.1007/s00282-997-0085-5
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DOI: https://doi.org/10.1007/s00282-997-0085-5