Conclusion
Therapy is becoming more effective as it is increasingly tailored to both the degree of activity, or disease extent, and the specific syndrome. As acute mortality has decreased, the need to look beyond the immediate flare has supported the use of staged regimes using combinations of drugs which can diminish toxicity. However, the residual mortality, morbidity and high relapse rate suggest there is a continuing need to improve these regimes.
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Carruthers, D.M., Bacon, P. Combination therapy in autoimmune disease: vasculitis. Springer Semin Immunopathol 23, 91–108 (2001). https://doi.org/10.1007/s002810100057
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DOI: https://doi.org/10.1007/s002810100057