Skip to main content

Advertisement

Log in

Activation of skin dendritic cells by immunostimulatory DNA

  • Published:
Springer Seminars in Immunopathology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Afonso LCC, Scharton TM, Vieira LW, Wysocka M, Trinchieri G, Scott P (1994) The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235

    Article  PubMed  CAS  Google Scholar 

  2. Bailas ZK, Rasmussen WL, Krieg AM (1996) Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 157:1840

    Google Scholar 

  3. Bendigs S, Salzer U, Lipford GB, Wagner H, Heeg K (1999) CpG-oligodeoxynucleotides co-stimulate primary T cells in the absence of antigen-presenting cells. Eur J Immunol 29:1209

    Article  PubMed  CAS  Google Scholar 

  4. Casares S, Inaba K, Brumeanu T-D, Steinman RM, Bona CA (1997) Antigen presentation by dendritic cells after immunization with DNA encoding a major histocompatibility complex class II-restricted viral epitope. J Exp Med 186:1481

    Article  PubMed  CAS  Google Scholar 

  5. Chace JH, Hooker NA, Mildenstein KL, Krieg AM, Cowdery JS (1997) Bacterial DNA-induced NK cell IFN-y production is dependent on macrophage secretion of IL-12. Clin Immunol Immunopathol 84:185c

    Google Scholar 

  6. Chu RS, Targoni OS, Krieg AM, Lehmann PV, Harding CV (1997) CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Thl) immunity. J Exp Med 186:1623

    Article  PubMed  CAS  Google Scholar 

  7. Condon C, Watkins SC, Celluzzi CM, Thompson K, Falo LD Jr (1996) DNA-based immunization by in vivo transfection of dendritic cells. Nat Medicine 2:1122

    Article  CAS  Google Scholar 

  8. Cowdery JS, Chace JH, Yi A-K, Krieg AM (1996) Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J Immunol 156:4570

    PubMed  CAS  Google Scholar 

  9. Cumberbatch M, Fielding I, Kimber I (1994) Modulation of epidermal Langerhans cell frequency by tumor necrosis factor-α. Immunology 81:395

    PubMed  CAS  Google Scholar 

  10. Davis HL, Weeranta R, Waldschmidt TJ, Tygrett L, Schorr J, Krieg AM (1998) CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J Immunol 160:870

    PubMed  CAS  Google Scholar 

  11. Enk AH, Angeloni VL, Udey MC, Katz SI (1993) An essential role for Langerhans cell-derived IL-Iß in the initiation of primary immune responses in skin. J Immunol 150:3698

    PubMed  CAS  Google Scholar 

  12. Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HL (1993) DNA Vaccines: Protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sei USA 90:11478

    Article  CAS  Google Scholar 

  13. Gurunathan S, Sacks DL, Brown DR, Reiner SL, Charest H, Glaichenhaus N, Seder RA (1997) Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med 186:1137

    Article  PubMed  CAS  Google Scholar 

  14. Halpern MD, Kurlander RJ, Pisetsky DS (1996) Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-α. Cell Immunol 167:72

    Article  PubMed  CAS  Google Scholar 

  15. Hengge UR, Chan EF, Foster RA, Walker PS, Vogel JC (1995) Cytokine gene expression in epidermis with biological effects following injection of naked DNA. Nat Genet 10:161

    Article  PubMed  CAS  Google Scholar 

  16. Hengge UR, Walker PS, Vogel JC (1996) Expression of naked DNA in human, pig, and mouse skin. J Clin Invest 97:2911

    Article  PubMed  CAS  Google Scholar 

  17. Jakob T, Saitoh A, Udey MC (1997) E-cadherin-mediated adhesion involving Langerhans cell-like dendritic cells expanded from murine fetal skin. J Immunol 159:2693

    PubMed  CAS  Google Scholar 

  18. Jakob T, Udey MC (1998) Regulation of E-cadherin-mediated adhesion in Langerhans cell-like dendritic cells by inflammatory mediators that mobilize Langerhans cells in vivo. J Immunol 160:4067

    PubMed  CAS  Google Scholar 

  19. Jakob T, Walker PS, Krieg AM, Udey MC, Vogel JC (1998) Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Thl responses by immunostimulatory DNA. J Immunol 161:3042

    PubMed  CAS  Google Scholar 

  20. Klinman DM, Yi A-K, Beaucage SL, Conover J, Krieg AM (1996) CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sei USA 93:2879

    Article  CAS  Google Scholar 

  21. Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, Koretzky GA, Klinman DM (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546

    Article  PubMed  CAS  Google Scholar 

  22. Lipford GB, Bauer M, Blank C, Reiter R, Wagner H, Heeg K (1997) CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvant. Eur J Immunol 94:2340

    Article  Google Scholar 

  23. Locksley RM, Scott P (1991) Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol Today 12:A58

    Google Scholar 

  24. Macatonia SE, Knight SC, Edwards AJ, Griffiths S, Fryer P (1987) Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate: functional and morphologic studies. J Exp Med 166:16545

    Article  Google Scholar 

  25. McClements WL, Armstrong ME, Keys RD, Liu MA (1996) Immunization with DNA vaccines encoding glycoprotein D or glycoprotein B, alone or in combination, induces protective immunity in animal models of herpes simplex virus-2 disease. Proc Natl Acad Sei USA 93:11414

    Article  CAS  Google Scholar 

  26. Nabors GS, Afonso LCC, Farrell JP, Scott P (1995) Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc Natl Acad Sei USA 92:3142

    Article  CAS  Google Scholar 

  27. Pisetsky DS (1996) Immune activation by bacterial DNA: a new genetic code. Immunity 5:303

    Article  PubMed  CAS  Google Scholar 

  28. Raz E, Carson DA, Parker SE, Parr TB, Abai AM, Aichinger G, Gromkowski SH, Singh M, Lew D, Yankauckas MA, Baird SM, Rhodes GH (1994) Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc Natl Acad Sei USA 91:9519

    Article  CAS  Google Scholar 

  29. Raz E, Tighe H, Sato Y, Corr M, Dudler JA, Roman M, Swain SL, Spiegelberg HL, Carson DA (1996) Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sei USA 93:5141

    Article  CAS  Google Scholar 

  30. Reed SG, Scott P (1993) T-cell and cytokine responses in leishmaniasis. Curr Opin Immunol 5:524

    Article  PubMed  CAS  Google Scholar 

  31. Reiner SL, Locksley RM (1995) The regulation of immunity to Leishmania major. Annu Rev Immunol 13: 151

    Article  PubMed  CAS  Google Scholar 

  32. Roake JA, Rao AS, Morris PJ, Larsen CP, Hankins DF, Austyn JM (1995) Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor and interleukin-1. J Exp Med 181:2237

    Article  PubMed  CAS  Google Scholar 

  33. Roman M, Martin-Orozco G, Goodman JS, Nguyen M-D, Sato Y, Ronaghy A, Kornbluth RS, Richman DD, Carson DA, Raz E (1997) Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat Medicine 3:849

    Article  CAS  Google Scholar 

  34. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen M-D, Silverman GJ, Lotz M, Carson DA, Raz E (1996) Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352

    Article  PubMed  CAS  Google Scholar 

  35. Scharton-Kersten T, Afonso LCC, Wysocka M, Trinchieri G, Scott P (1995) IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol 154:53230

    Google Scholar 

  36. Scharton-Kersten T, Scott P (1995) The role of the innate immune response in Thl cell development following Leishmania major infection. J Leukoc Biol 57:515

    PubMed  CAS  Google Scholar 

  37. Sparwasser T, Koch E, Vabulas RM, Heeg K, Lipford GB, Ellwart JW, Wagner H (1998) Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28:2045

    Article  PubMed  CAS  Google Scholar 

  38. Sparwasser T, Miethke T, Lipford G, Erdmann A, Hacker H, Heeg K, Wagner H (1997) Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-mediated shock. Eur J Immunol 27:1671

    Article  PubMed  CAS  Google Scholar 

  39. Stacey KJ, Sweet MJ, Hume DA (1996) Macrophages ingest and are activated by bacterial DNA. J Immunol 157:2116

    PubMed  CAS  Google Scholar 

  40. Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271

    Article  PubMed  CAS  Google Scholar 

  41. Sun S, Kishimoto H, Sprent J (1998) DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen. J Exp Med 187:1145

    Article  PubMed  CAS  Google Scholar 

  42. Tang A, Amagai M, Granger LG, Stanley JR, Udey MC (1993) Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin. Nature 361:82

    Article  PubMed  CAS  Google Scholar 

  43. Tang D, De Vit M, Johnston SA (1992) Genetic immunization is a simple method for eliciting an immune response. Nature 356:152

    Article  PubMed  CAS  Google Scholar 

  44. Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Feigner PL, Dwarki VJ, Gromkowski SH, Deck RR, De Witt CM, Friedman A, Hawe LA, Leander KR, Martinez D, Perry HC, Shiver JW, Montgomery DL, Liu MA (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745

    Article  PubMed  CAS  Google Scholar 

  45. Walker PS, Scharton-Kersten T, Krieg AM, Love-Homan L, Rowton ED, Udey MC, Vogel JC (1999) Immunostimulatory oligonucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12-and IFN-γ-dependent mechanisms. Proc Natl Acad Sei USA 96:6970

    Article  CAS  Google Scholar 

  46. Weiner GJ, Liu H-M, Wooldridge JE, Dahle CE, Krieg AM (1997) Immunostimulatory oligodeoxy-nucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc Natl Acad Sei USA 94:10833

    Article  CAS  Google Scholar 

  47. Xu D, Liew FY (1995) Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major. Immunology 84: 173

    PubMed  CAS  Google Scholar 

  48. Zimmermann S, Egeter O, Hausmann S, Lipford GB, Rocken M, Wagner H, Heeg K (1998) CpG oligodeoxynucleotides trigger protective and curative Thl responses in lethal murine leishmaniasis. J Immunol 160:3627

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vogel, J.C., Udey, M.C. Activation of skin dendritic cells by immunostimulatory DNA. Springer Semin Immunopathol 22, 45–54 (2000). https://doi.org/10.1007/s002810000027

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002810000027

Keywords

Navigation