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Resolution of uveitis

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Abstract

Autoimmune uveitis is a sight-threatening, rare disease, potentially leading to blindness. Uveitis is a synonym for intraocular inflammation, presenting as various clinical phenotypes with different underlying immune responses in patients, whereas different animal models usually represent one certain clinical and immunological type of uveitis due to genetic uniformity and the method of disease induction. T cells recognizing intraocular antigens initiate the disease, recruiting inflammatory cells (granulocytes, monocytes/macrophages) to the eyes, which cause the damage of the tissue. The treatment of uveitis so far aims at downregulation of inflammation to protect the ocular tissues from damage, and at immunosuppression to stop fueling T cell reactivity. Uveitis is usually prevented by specific mechanisms of the ocular immune privilege and the blood-eye-barriers, but once the disease is induced, mechanisms of the immune privilege as well as a variety of novel regulatory features including new Treg cell populations and suppressive cytokines are induced to downregulate the ocular inflammation and T cell responses and to avoid relapses and chronicity. Here we describe mechanisms of regulation observed in experimental animal models as well as detected in studies with peripheral lymphocytes from patients.

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Acknowledgments

We thank Stephan Thurau for critically reading the manuscript.

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  1. Section of Immunobiology, Department of Ophthalmology, University Hospital, LMU Munich, Mathildenstr, 8, 80336, Munich, Germany

    Gerhild Wildner & Maria Diedrichs-Möhring

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  1. Gerhild Wildner
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This article is a contribution to the special issue on Resolution of Inflammation in Chronic Diseases - Guest Editor: Markus Neurath

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Wildner, G., Diedrichs-Möhring, M. Resolution of uveitis. Semin Immunopathol 41, 727–736 (2019). https://doi.org/10.1007/s00281-019-00758-z

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