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Memory responses of innate lymphocytes and parallels with T cells

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Abstract

Natural killer (NK) cells are classified as innate immune cells, given their ability to rapidly respond and kill transformed or virally infected cells without prior sensitization. Recently, accumulating evidence suggests that NK cells also exhibit many characteristics similar to cells of the adaptive immune system. Analogous to T cells, NK cells acquire self-tolerance during development, express antigen-specific receptors, undergo clonal-like expansion, and can become long-lived, self-renewing memory cells with potent effector function providing potent protection against reappearing pathogens. In this review, we discuss the requirements for memory NK cell generation and highlight the similarities with the formation of memory T cells.

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Acknowledgements

We thank Clair Geary and Nicholas Adams for insightful discussions and the critical review of the manuscript.

Funding

M.R. was supported by a fellowship from the German Academic Exchange Service (DAAD; Germany). G.M.W. was supported by Deutsche Forschungsgemeinschaft DFG (Forschungsstipendium GZ: WI 4927/1-1). J.C.S. was supported by the Ludwig Center for Cancer Immunotherapy, the Burroughs Wellcome Fund, the American Cancer Society, and grants from the NIH (AI100874, AI130043, AI123658, and P30CA008748).

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  1. Moritz Rapp and Gabriela M. Wiedemann contributed equally to this work.

Authors and Affiliations

  1. Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Zurich, Switzerland

    Moritz Rapp

  2. Immunology Program, Memorial Sloan Kettering Cancer Center, 408 East 69th Street, ZRC-1462, New York, NY, 10065, USA

    Moritz Rapp, Gabriela M. Wiedemann & Joseph C. Sun

  3. Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY, 10065, USA

    Joseph C. Sun

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  1. Moritz Rapp
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Correspondence to Joseph C. Sun.

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This article is a contribution to the special issue on Innate Lymphoid Cells in Inflammation and Immunity - Guest Editors: Jan-Eric Turner and Georg Gasteiger

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Rapp, M., Wiedemann, G.M. & Sun, J.C. Memory responses of innate lymphocytes and parallels with T cells. Semin Immunopathol 40, 343–355 (2018). https://doi.org/10.1007/s00281-018-0686-9

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