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Seminars in Immunopathology

, Volume 39, Issue 6, pp 605–613 | Cite as

Transfer of maternal immunity and programming of the newborn immune system

  • Madeleine F. Jennewein
  • Bahaa Abu-Raya
  • Yiwei Jiang
  • Galit Alter
  • Arnaud MarchantEmail author
Review

Abstract

As placental mammals, the pregnant women and the fetus have intense and prolonged interactions during gestation. There is increasing evidence that multiple molecular as well as cellular components originating in pregnant women are transferred to the fetus. The transfer of maternal antibodies has long been recognized as a central component of newborn immunity against pathogens. More recent studies indicate that inflammatory mediators, micronutrients, microbial products and maternal cells are transferred in utero and influence the fetal immune system. Together, these multiple signals are likely to form a complex network of interactions that program the neonatal immune system and tune its homeostatic regulation. Maternal disorders, in particular infectious diseases, modify these signals and may thereby alter immunity in early life. Understanding maternal programming of the newborn immune system could provide a basis for interventions promoting child health.

Keywords

Fetal immune system Pregnancy Maternal antibodies Inflammation Infectious diseases Microchimerism 

Notes

Acknowledgements

A.M. is research director at the Fund for Scientific Research, F.R.S.-FNRS, Belgium.

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Ragon Institute of MGH, MIT and HarvardCambridgeUSA
  2. 2.Vaccine Evaluation Center, BC Childrenʼs Hospital, Department of Pediatrics, Division of Infectious DiseasesUniversity of British ColumbiaVancouverCanada
  3. 3.Institute for Medical ImmunologyUniversité Libre de BruxellesCharleroiBelgium

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