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Trp channels and itch

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Abstract

Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently. The goal of the present review is to summarize our current understanding of the mechanisms of acute as well as chronic itch and classifications of the primary itch populations in relationship to transient receptor potential (Trp) channels, which play pivotal roles in multiple somatosensations. The convergent involvement of Trp channels in diverse itch signaling pathways suggests that Trp channels may serve as promising targets for chronic itch treatments.

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Acknowledgments

This work was supported by grants (DE022750 and NS054791) from the National Institutes of Health to X.D. X.D. is an investigator of the Howard Hughes Medical Institute. We thank Sarah L. Poynton for editing.

Conflict of Interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA

    Shuohao Sun & Xinzhong Dong

  2. Howard Hughes Medical Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, 21205, USA

    Xinzhong Dong

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  1. Shuohao Sun
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  2. Xinzhong Dong
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Correspondence to Xinzhong Dong.

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This article is a contribution to the Special Issue on the Role of TRP Ion Channels in Physiology and Pathology - Guest Editor: Armen Akopian

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Sun, S., Dong, X. Trp channels and itch. Semin Immunopathol 38, 293–307 (2016). https://doi.org/10.1007/s00281-015-0530-4

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