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Effector CD8 T cell immunity in microsporidial infection: a lone defense mechanism

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Abstract

Microsporidia is a group of pathogens, which can pose severe risks to the immunocompromised population such as HIV-infected individuals. The expertise to diagnose these pathogens is limited and therefore their prevalence is believed to be much higher than what is currently known. In a mouse model of infections, it has been reported that CD8 T cells are the primary effector cells responsible for protecting the infected host. As the infection is acquired via per-oral route, CD8 T cells in the gut compartment apparently act as a first line of defense against the pathogens. Thus, generation of a robust CD8 T cell response that exhibits polyfunctional ability is critical for host survival. In this review, we describe the effector CD8 T cells generated during microsporidial infection and underline the factors that may be essential for the elicitation of protective immunity against this understudied but significant pathogen. Overall, this review will highlight the necessity for a better understanding of the development of the CD8 T cell response in gut associated lymphoid tissue (GALT) and provide some insights into therapies that may be used to restore defective CD8 T cell functionality in an immunocompromised situation.

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Acknowledgments

This work was supported by NIH grants AI096978 and AI102711 to IAK.

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Authors and Affiliations

  1. Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC, 20037, USA

    Magali M. Moretto, Danielle I. Harrow & Imtiaz A. Khan

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  1. Magali M. Moretto
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  2. Danielle I. Harrow
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  3. Imtiaz A. Khan
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Correspondence to Magali M. Moretto.

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This article is a contribution to the Special Issue on : CD8+ T-cell Responses against Non-Viral Pathogens - Guest Editors: Fidel Zavala and Imtiaz A. Khan

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Moretto, M.M., Harrow, D.I. & Khan, I.A. Effector CD8 T cell immunity in microsporidial infection: a lone defense mechanism. Semin Immunopathol 37, 281–287 (2015). https://doi.org/10.1007/s00281-015-0482-8

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