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Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases

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Abstract

A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical negative modulator of TCR signaling encoded by the PTPN22 gene. The functional analysis of autoimmune-associated PTPN22 genetic variants suggests that genetic variability of TCR signal transduction contributes to the pathogenesis of autoimmunity in humans.

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Acknowledgements

This work was supported by NIH grant R01AI070544 to N.B. This is publication #1257 from the La Jolla Institute for Allergy and Immunology.

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  1. Tomas M. Mustelin

    Present address: , Amgen Washington, Seattle, WA, 98119, USA

Authors and Affiliations

  1. Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA

    Stephanie M. Stanford & Nunzio Bottini

  2. Sanford-Burnham Medical Research Institute, Infectious and Inflammatory Disease Center, La Jolla, CA, 92037, USA

    Tomas M. Mustelin

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  1. Stephanie M. Stanford
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Correspondence to Nunzio Bottini.

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Stanford, S.M., Mustelin, T.M. & Bottini, N. Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases. Semin Immunopathol 32, 127–136 (2010). https://doi.org/10.1007/s00281-010-0201-4

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  • DOI: https://doi.org/10.1007/s00281-010-0201-4

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