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Cytokine-adjuvanted HIV-DNA vaccination strategies

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Abstract

This review highlights some of the most common cytokines currently being tested as adjuvants in HIV-1-DNA vaccine regimens. We discuss their use in both the prophylactic and therapeutic setting. Finally, we describe a novel dendritic cell-targeted vaccine candidate for HIV-1 treatment and prevention called DermaVir and explore the combination of the DermaVir technology with the cytokine adjuvants interleukin-7 and interleukin-15.

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Acknowledgments

The authors would like to thank Sylva Petrocchi and Gabriela Barbieri for their editorial assistance.

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Authors and Affiliations

  1. Research Institute for Genetic and Human Therapy (RIGHT), Pavia, Italy

    Franco Lori, Sandra A. Calarota & Laurene M. Kelly

  2. Research Institute for Genetic and Human Therapy (RIGHT), Bethesda, MD, USA

    Franco Lori, Sandra A. Calarota & Laurene M. Kelly

  3. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    David B. Weiner & Sandra A. Calarota

  4. Genetic Immunity, LLC, Washington, DC, USA

    Julianna Lisziewicz

  5. Genetic Immunity, LLC, Budapest, Hungary

    Julianna Lisziewicz

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  1. Franco Lori
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  2. David B. Weiner
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  3. Sandra A. Calarota
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  4. Laurene M. Kelly
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  5. Julianna Lisziewicz
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Correspondence to Franco Lori.

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Lori, F., Weiner, D.B., Calarota, S.A. et al. Cytokine-adjuvanted HIV-DNA vaccination strategies. Springer Semin Immun 28, 231–238 (2006). https://doi.org/10.1007/s00281-006-0047-y

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