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Superiority of cyclosporin A over PSC-833 in enhancement of VP-16 efficacy in murine tumors in vivo

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Abstract

 PSC-833, a non immunosuppressive analogue of cyclosporin A, is an effective modulator of the multidrug-resistant tumor phenotype. Since both PSC-833 and cyclosporin A also enhance the cytotoxicity of VP-16 against drug sensitive L1210 leukemia cells in vitro we compared these agents as modulators of VP-16 efficacy in vivo. Compared to VP-16 treatment alone both PSC-833 and cyclosporin A significantly altered the survival of L1210 leukemia-bearing BDF/1 mice and Lewis lung carcinoma-bearing C57/Bl mice. Cyclosporin A enhanced VP-16 efficacy whereas PSC-833 impaired VP-16 efficacy against these murine tumors. Possible reasons for these disparate effects are discussed.

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Authors and Affiliations

  1. Department of Medicine, University of California, Irvine, Irvine, California 92717, USA Fax (714) 824-2990, , , , , , US

    L. M. Slater, Paula Sweet, Marie Stupecky & Kathyrn Osann

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  1. L. M. Slater
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  2. Paula Sweet
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  3. Marie Stupecky
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  4. Kathyrn Osann
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Received: 8 September 1995 / Accepted: 31 July 1996

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Slater, L., Sweet, P., Stupecky, M. et al. Superiority of cyclosporin A over PSC-833 in enhancement of VP-16 efficacy in murine tumors in vivo. Cancer Chemother Pharmacol 39, 452–454 (1997). https://doi.org/10.1007/s002800050597

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  • DOI: https://doi.org/10.1007/s002800050597

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