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Alternative dosing regimens for atezolizumab: right dose, wrong frequency

Cancer Chemotherapy and Pharmacology volume 84, pages 1153–1155 (2019)Cite this article

Abstract

The population pharmacokinetics of atezolizumab demonstrate that the trough concentrations are well above the putative target of 6 µg/ml. Thus, alternative dosing schedules are indeed of interest, focusing on reducing the frequency to allow greater patient convenience and reduced costs.

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References

  1. Morrissey KM, Marchand M, Patel H, Zhang R, Wu B, Chan HP, Mecke A, Girish S, Jin JY, Winter HR, Bruno R (2019) Alternative dosing regimens for atezolizumab: an example of model-informed drug development in the postmarketing setting. Cancer Chemother Pharmacol. https://doi.org/10.1007/s00280-019-03954-8

    Article  PubMed  Google Scholar 

  2. Ratain MJ, Goldstein DA, Lichter AS (2019) Interventional pharmacoeconomics: a new discipline for a cost-constrained environment. JAMA Oncol. https://doi.org/10.1001/jamaoncol.2019.1341

    Article  PubMed  Google Scholar 

  3. Ratain MJ, Goldstein DA (2018) Time is money: optimizing the scheduling of nivolumab. J Clin Oncol. https://doi.org/10.1200/JCO.18.00045:JCO1800045

    Article  PubMed  PubMed Central  Google Scholar 

  4. Deng R, Bumbaca D, Pastuskovas CV, Boswell CA, West D, Cowan KJ, Chiu H, McBride J, Johnson C, Xin Y, Koeppen H, Leabman M, Iyer S (2016) Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor. MAbs 8(3):593–603. https://doi.org/10.1080/19420862.2015.1136043

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Powles T, Eder JP, Fine GD, Braiteh FS, Loriot Y, Cruz C, Bellmunt J, Burris HA, Petrylak DP, Teng SL, Shen X, Boyd Z, Hegde PS, Chen DS, Vogelzang NJ (2014) MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature 515(7528):558–562. https://doi.org/10.1038/nature13904

    Article  CAS  PubMed  Google Scholar 

  6. Spigel DR, Gettinger SN, Horn L, Herbst RS, Gandhi L, Gordon MS, Cruz C, Conkling P, Cassier PA, Antonia SJ, Burris HA, Fine GD, Mokatrin A, Kowanetz M, Shen X, Chen DS, Soria J-C (2013) Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 31(15):8008. https://doi.org/10.1200/jco.2013.31.15_suppl.8008

    Article  Google Scholar 

  7. Li H, Yu J, Liu C, Liu J, Subramaniam S, Zhao H, Blumenthal GM, Turner DC, Li C, Ahamadi M, de Greef R, Chatterjee M, Kondic AG, Stone JA, Booth BP, Keegan P, Rahman A, Wang Y (2017) Time dependent pharmacokinetics of pembrolizumab in patients with solid tumor and its correlation with best overall response. J Pharmacokinet Pharmacodyn 44(5):403–414. https://doi.org/10.1007/s10928-017-9528-y

    Article  CAS  PubMed  Google Scholar 

  8. Liu C, Yu J, Li H, Liu J, Xu Y, Song P, Liu Q, Zhao H, Xu J, Maher VE, Booth BP, Kim G, Rahman A, Wang Y (2017) Association of time-varying clearance of nivolumab with disease dynamics and its implications on exposure response analysis. Clin Pharmacol Ther 101(5):657–666. https://doi.org/10.1002/cpt.656

    Article  CAS  PubMed  Google Scholar 

  9. Ogasawara K, Newhall K, Maxwell SE, Dell’Aringa J, Komashko V, Kilavuz N, Delarue R, Czuczman M, Sternas L, Rose S, Beach CL, Novick S, Zhou S, Palmisano M, Li Y (2019) Population pharmacokinetics of an anti-PD-L1 antibody, durvalumab in patients with hematologic malignancies. Clin Pharmacokinet 1:5–9. https://doi.org/10.1007/s40262-019-00804-x

    Article  CAS  Google Scholar 

  10. Baverel PG, Dubois VFS, Jin CY, Zheng Y, Song X, Jin X, Mukhopadhyay P, Gupta A, Dennis PA, Ben Y, Vicini P, Roskos L, Narwal R (2018) Population pharmacokinetics of durvalumab in cancer patients and association with longitudinal biomarkers of disease status. Clin Pharmacol Ther 103(4):631–642. https://doi.org/10.1002/cpt.982

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Tel Aviv University, Tel Aviv, Israel

    Daniel A. Goldstein

  2. Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel

    Daniel A. Goldstein

  3. Department of Health Policy and Management, Gillings School of Public Health, University of North Carolina, Chapel Hill, USA

    Daniel A. Goldstein

  4. The University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL, 60637, USA

    Mark J. Ratain

Authors
  1. Daniel A. Goldstein
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  2. Mark J. Ratain
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Correspondence to Mark J. Ratain.

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Conflict of interest

M.J.R. reports grants from AbbVie, personal fees from Aptevo, personal fees from Cyclacel, other from BeiGene, grants from Dicerna, personal fees from multiple generic pharmaceutical companies, grants from Genentech, personal fees from Pneuma Respiratory, outside the submitted work; and Co-founder and Director, Value in Cancer Care Consortium (Vi3C, www.vi3c.org). D.A.G. declares that he has no conflict of interest.

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This article refers to online published article available at https://doi.org/10.1007/s00280-019-03954-8.

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Goldstein, D.A., Ratain, M.J. Alternative dosing regimens for atezolizumab: right dose, wrong frequency. Cancer Chemother Pharmacol 84, 1153–1155 (2019). https://doi.org/10.1007/s00280-019-03971-7

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  • DOI: https://doi.org/10.1007/s00280-019-03971-7

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