Animals living in polluted environments are a potential source of anti-tumor molecule(s)
Despite advances in therapeutic interventions and supportive care, the morbidity and mortality associated with cancer have remained significant. Thus, there is a need for newer and more powerful anti-tumor agents. The search for new anti-tumor compounds originating from natural resources is a promising research area. Animals living in polluted environments are a potent source of anti-tumor agents. Under polluted milieus, species such as crocodiles, feed on rotten meat, are exposed to heavy metals, endure high levels of radiation, and are among the very few species to survive the catastrophic Cretaceous-Tertiary extinction event with a prolonged lifespan. Thus, it is reasonable to speculate that animals such as crocodiles have developed mechanisms to defend themselves against cancer. The discovery of antitumor activity in animals such as crocodiles, whales, sharks, etc. will stimulate research in finding therapeutic molecules from unusual sources, and has potential for the development of novel antitumor compound(s) that may also overcome current drug resistance. Nevertheless, intensive research in the next few years will be required to realize these expectations.
KeywordsAnticancer agents Animals-based compounds Cancer resistance Antitumor molecule(s)
Compliance with ethical standards
Conflict of interest
SJ declares that she has no conflict of interest. NAK declares that he has no conflict of interest. RS declares that she has no conflict of interest.
This study was funded by Sunway University, Malaysia, grant FST-2015-05.
This article does not contain any studies with human participants and animals performed by any of the authors.
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