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Phase II study of use of a single cycle of induction chemotherapy and concurrent chemoradiotherapy containing capecitabine/cisplatin followed by surgery for patients with resectable esophageal squamous cell carcinoma: long-term follow-up data

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Abstract

Purpose

This phase II study evaluated the feasibility and efficacy of one cycle of induction chemotherapy, followed by concurrent chemoradiotherapy (CRT) featuring capecitabine/cisplatin, followed in turn by surgery, in the treatment of patients with resectable esophageal squamous cell carcinoma.

Methods

Between March 2003 and April 2005, 54 patients with stage II or III esophageal cancer were treated with induction chemotherapy (cisplatin 60 mg/m2 on day 1; capecitabine 1,000 mg/m2 bid on days 1–14) followed by concurrent radiotherapy (46 Gy in 23 fractions) and chemotherapy (cisplatin 30 mg/m2 on days 1, 8, 15, and 22; capecitabine 800 mg/m2 bid 5 days/week). Surgery was performed within 8 weeks of the end of radiotherapy.

Results

Median age of the patients was 64.5 years (range, 45–74 years). After CRT, 52 patients (96%) showed a clinical response, including 26 (48%) who exhibited a complete response (CR). Surgery was performed on 41 patients (76%), with 20 (37%) achieving pathologic CR and 3 (6%) dying of postoperative pneumonia. At a median follow-up time of 74.2 months (range, 64.3–84.8 months), 16 patients (30%) had experienced tumor recurrence and 36 (67%) had died. Of the 41 patients who underwent esophagectomy, 5 (12%) had exclusively locoregional disease and 7 (17%) had distant metastasis, whereas no one had both. The 5-year progression-free and overall survival rates were 30.2% (95% confidence interval [CI], 18.0–42.4%) and 37.0% (95% CI, 24.1–50.0%), respectively.

Conclusions

A trimodal approach, consisting of a single cycle of induction chemotherapy, CRT containing capecitabine and cisplatin, and surgery, was feasible and effective in patients with resectable esophageal squamous cell carcinoma.

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Authors and Affiliations

  1. Department of Oncology, University of Ulsan College of Medicine, Esophageal Cancer Study Group (ECSG), Asan Medical Center, 86, Asanbyeongwon-gil, Songpa-gu, Seoul, 138-736, Korea

    Dong Hoe Koo, Dok-Hyun Yoon & Sung-Bae Kim

  2. Department of Thoracic Surgery, University of Ulsan College of Medicine, Esophageal Cancer Study Group (ECSG), Asan Medical Center, Seoul, Korea

    Seung-Il Park & Yong-Hee Kim

  3. Department of Radiation Oncology, University of Ulsan College of Medicine, Esophageal Cancer Study Group (ECSG), Asan Medical Center, Seoul, Korea

    Jong Hoon Kim

  4. Department of Gastroenterology, University of Ulsan College of Medicine, Esophageal Cancer Study Group (ECSG), Asan Medical Center, Seoul, Korea

    Hwoon-Yong Jung, Gin-Hyug Lee, Kee Don Choi & Ho June Song

  5. Department of Radiology, University of Ulsan College of Medicine, Esophageal Cancer Study Group (ECSG), Asan Medical Center, Seoul, Korea

    Ho Young Song & Ji Hoon Shin

  6. Department of Pathology, University of Ulsan College of Medicine, Esophageal Cancer Study Group (ECSG), Asan Medical Center, Seoul, Korea

    Kyung-Ja Cho

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  1. Dong Hoe Koo
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Correspondence to Sung-Bae Kim.

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Koo, D.H., Park, SI., Kim, YH. et al. Phase II study of use of a single cycle of induction chemotherapy and concurrent chemoradiotherapy containing capecitabine/cisplatin followed by surgery for patients with resectable esophageal squamous cell carcinoma: long-term follow-up data. Cancer Chemother Pharmacol 69, 655–663 (2012). https://doi.org/10.1007/s00280-011-1750-5

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