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Intrathoracic injection of paclitaxel for a patient with stage IV serous ovarian cancer: a case report

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Abstract

Background

There have so far only been few reports on the intrathoracic injection (IT) of paclitaxel for ovarian cancer.

Case

The patient was treated with IT paclitaxel to control a large volume of pleural effusion as neoadjuvant chemotherapy. A total of 220 mg (110 mg in each thoracic cavity) of paclitaxel was administrated and the pleural effusion dramatically decreased. The intrathoracic concentration of paclitaxel was 1,524.0, 107.5, 8.1, 11.0 and 3.8 μm/l at 0, 24, 48, 72 and 96 h, respectively. The plasma concentration was 0.05, 0.11, 0.07, 0.04 and 0.02 μm/l, respectively.

Conclusion

An extremely high concentration was maintained over 96 h and there was slight transition into general circulation following IT administration. IT paclitaxel might be effective in some patients with ovarian serous adenocarcinoma who have a refractory tumor in the thoracic cavity.

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References

  1. Perng RP, Wu MF, Lin SY, Chen YM, Lin JY, Whang-Peng J (1997) A phase I feasibility and pharmacokinetic study of intrapleural paclitaxel in patients with malignant pleural effusions. Anticancer Drugs 8(6):565–573

    Article  PubMed  CAS  Google Scholar 

  2. Perng RP, Chen YM, Wu MF, Chou KC, Lin WC, Liu JM et al (1998) Phase II trial of intrapleural paclitaxel injection for non-small-cell lung cancer patients with malignant pleural effusions. Respir Med 92(3):473–479

    Article  PubMed  CAS  Google Scholar 

  3. Ohta Y, Shimizu Y, Matsumoto I, Watanabe G (2006) Management of malignant pleural effusion by multimodality treatment including the use of paclitaxel administered by 24-hour intrathoracic infusion for patients with carcinomatous pleuritis. J Exp Clin Cancer Res 25(1):15–19

    PubMed  CAS  Google Scholar 

  4. Gianni L, Kearns CM, Giani A, Capri G, Vigano L, Lacatelli A et al (1995) Nonlinear pharmacokinetics and metabolism of paclitaxel and its pharmacokinetic/pharmacodynamic relationships in humans. J Clin Oncol 13(1):180–190

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Graduate School of Medicine, Hokkaido University, North15, West7, Sapporo, Hokkaido, Japan

    Takashi Mitamura, Masayoshi Hosaka, Mahito Takeda, Hidemichi Watari & Noriaki Sakuragi

Authors
  1. Takashi Mitamura
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  2. Masayoshi Hosaka
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  3. Mahito Takeda
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  4. Hidemichi Watari
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  5. Noriaki Sakuragi
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Corresponding author

Correspondence to Takashi Mitamura.

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Mitamura, T., Hosaka, M., Takeda, M. et al. Intrathoracic injection of paclitaxel for a patient with stage IV serous ovarian cancer: a case report. Cancer Chemother Pharmacol 64, 169–170 (2009). https://doi.org/10.1007/s00280-009-0951-7

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  • DOI: https://doi.org/10.1007/s00280-009-0951-7

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