Skip to main content

Advertisement

SpringerLink
Log in

Sonodynamic therapy on chemically induced mammary tumor: pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of gallium–porphyrin complex ATX-70

  • Original Article
  • Published:
Cancer Chemotherapy and Pharmacology Aims and scope Submit manuscript

Abstract

Sonodynamically induced antitumor effect of a gallium porphyrin complex, ATX-70 was evaluated on a chemically induced mammary tumor in Sprague–Dawley rats. The timing of 24 h after the administration of ATX-70 was chosen for ultrasonic exposure, based on pharmacokinetic analysis of ATX-70 concentrations in the tumor, plasma, skin, and muscle. At an ATX-70 dose not less than 2.5 mg/kg and at a free-field ultrasonic intensity not less than 3 W/cm2, the synergistic effect between ATX-70 administration and ultrasonic exposure on the tumor growth inhibition was significant. These results suggest that ATX-70 is a potential sonosensitizer for sonodynamic treatment of spontaneous mammary tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

Abbreviations

PDT::

Photodynamic therapy

SDT::

Sonodynamic therapy

DMBA::

7,12-Dimethylanthracene

ATX-70::

7,12-Bis(1-decyloxyethyl)-Ga(III)-3,8,13,17-tetramethyl-porphyrin-2,18-dipropionyl diaspartic acid

References

  1. Abe H, Kuroki K, Tachibana K, Awasthi A, Ueno A, Matsumoto H, Imakiire T, Yamauchi Y, Yamada H, Ariyoshi A, Kuroki M (2002) Targeted sonodynamic therapy of cancer using a photosensitizer conjugated with antibody against carcinoembryonic antigen. Anticancer Res 22:1575–1580

    PubMed  CAS  Google Scholar 

  2. Agarwal R, Athar M, Elmets CA, Bickers DR, Mukhtar H (1990) Photodynamic therapy of chemically- and ultraviolet B radiation-induced murine skin papillomas by chloroaluminum phthalocyanine tetrasulfonate. Photochem Photobiol 56:43–50

    Google Scholar 

  3. Bellnier DA, Ho YK, Panday RK, Missert JR, Dougherty TJ (1989) Distribution and elimination of Photofrin II in mice. Photochem Photobiol 50:221–228

    Article  PubMed  CAS  Google Scholar 

  4. Brueggemeier RW, Li PK (1990) Effects of the aromatase inhibitor 7 alpha- (4′-amino) phenylthio-4-androstene-3, 17-dione on 7,12-dimethylbenz (a) anthracene-induced mammary carcinoma in rats. Cancer Res 48:6808–6810

    Google Scholar 

  5. Dougherty TJ (1993) Photodynamic therapy. Photochem Photobiol 58:895–905

    PubMed  CAS  Google Scholar 

  6. Jin ZH, Miyoshi N, Ishiguro K, Umemura S, Kawabata K, Yumita N, Sakata I, Takaoka K, Udagawa T, Nakajima S, Tajiri H, Ueda K, Fukuda M, Kumakiri M (2000) Combination effect of photodynamic and sonodynamic therapy on experimental skin squamous cell carcinoma in C3H/HeN mice. J Dermatol 27:294–306

    PubMed  CAS  Google Scholar 

  7. Kessel D (1986) Porphyrin-lipoprotein association as a factor in porphyrin loacatization. Cancer Lett 33:183–188

    Article  PubMed  CAS  Google Scholar 

  8. Nakajima S, Maeda T, Omote Y, Hayashi H, Yamazaki K, Kobo Y, Takemura S, Shindo Y, Sakata I (1989) Tumor localizing Ga–porphyrin complex (ATX-70) as a new photosensitizer excited with YAG-laser. J Jpn Soc Laser Med 10:225–228

    Google Scholar 

  9. Okuyama N, Sasamoto S, Kato N, Takagi K, Yamazaki S, Tsujimoto S, Yumita N, Nishigaki R, K.Sasaki, Umemura S (2000) The effect of sonodynamic therapy on rat mammary cancer (in Japanese). J Med Ultrasonics 27:1465–1469

    Google Scholar 

  10. Roy RA, Atchley AA, Crum LA, Fowlkes JB, Reidy JJ (1985) A precise technique for the measurement of acoustic cavitation thresholds and some preliminary results. J Acoust Soc Am 78:1799–1805

    Article  PubMed  CAS  Google Scholar 

  11. Umemura S, Yumita N, Nishigaki R, Umemura K (1990) Mechanism of cell damage by ultrasound in combination with hematoporphyrin. Jpn J Cancer Res 81:962–966

    PubMed  CAS  Google Scholar 

  12. Umemura K, Yumita N, Nishigaki R, Umemura S (1996) Sonodynamically induced antitumor effect of pheophorbide a. Cancer Lett 102:151–157

    Article  PubMed  CAS  Google Scholar 

  13. Umemura S, Yumita N, Nishigaki R (1993) Enhancement of ultrasonically induced cell damage by a gallium–porphyrin complex, ATX-70. Jpn J Cancer Res 84:582–588

    PubMed  CAS  Google Scholar 

  14. Umemura S, Sasaki K, Kawabata K (1995) Reduction of threshold for producing sonodynamic tissue damage by second-harmonic superimposition. In: Proceedings of 1995 IEEE ultrasonics symposium, pp 1567–1570

  15. Yumita N, Nishigaki R, Umemura K, Umemura S (1989) Hematoporphyrin as a sensitizer of cell damaging effect of ultrasound. Jpn J Cancer Res 80:219–222

    PubMed  CAS  Google Scholar 

  16. Yumita N, Nishigaki R, Umemura K, Umemura S (1990) Synergetic effect of ultrasound and hematoporphyrin on sarcoma 180. Jpn J Cancer Res 81:304–308

    PubMed  CAS  Google Scholar 

  17. Yumita N, Sasaki K, Umemura S, Nishigaki R (1996) Sonodynamically induced antitumor effect of a gallium–porphyrin complex, ATX-70. Jpn J Cancer Res 87:310–316

    PubMed  CAS  Google Scholar 

  18. Yumita N, Umemura S (2000) Sonodynamic therapy with photofrin II on AH130 solid tumor. Pharmacokinetics, tissue distribution and sonodynamic antitumoral efficacy of photofrin II. Cancer Chemother Pharmacol 51:74–78

    Google Scholar 

  19. Yumita N, Nishigaki R, Sakata I, Nakajima S, Umemura S (2000) Sonodynamically induced antitumor effect of 4-formyloximethylidene-3-hydroxy-2-vinyl-deuterio-porphynyl(IX)-6,7-diaspartic acid (ATX-S10). Jpn J Cancer Res 91:255–260

    PubMed  CAS  Google Scholar 

  20. Yumita N, Okuyama N, Sasaki K, Umemura S (2004) Sonodynamic therapy on chemically induced mammary tumor: pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of porfimer sodium. Cancer Sci 95:765–769

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Pharmaceutical Sciences, Toho University, 2−2−1 Miyama, Funabashi, Chiba, 274−8510, Japan

    Nagahiko Yumita

  2. School of Medicine, Toho University, 5−24−1 Oumori-nishi, Tokyo, 274, Japan

    Nobuo Okuyama

  3. Central Research Laboratory, Hitachi, Ltd, 1−280 Higashi-Koigakubo, Kokubunji, Tokyo, 185-8601, Japan

    Kazuaki Sasaki

  4. School of Health Sciences, Faculty of Medicine, Kyoto University, 53 Kawahara-cho, Shogo-in, Sakyo-ku, Kyoto, 606-8507, Japan

    Shin-ichiro Umemura

Authors
  1. Nagahiko Yumita
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nobuo Okuyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kazuaki Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shin-ichiro Umemura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shin-ichiro Umemura.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yumita, N., Okuyama, N., Sasaki, K. et al. Sonodynamic therapy on chemically induced mammary tumor: pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of gallium–porphyrin complex ATX-70. Cancer Chemother Pharmacol 60, 891–897 (2007). https://doi.org/10.1007/s00280-007-0436-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00280-007-0436-5

Keywords

Search

Navigation