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Cryptic Mucor infection leading to massive cerebral infarction at initiation of antileukemic chemotherapy

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Abstract

 A 74-year-old man with newly diagnosed acute myelogenous leukemia unexpectedly suffered a massive cerebral infarct on day 2 of induction chemotherapy. Clinically, the hemorrhagic infarct was thought to be due to leukostasis and thrombocytopenia. Necropsy, however, revealed that Zygomycetes-type hyphae had infiltrated cerebral vessels in and near the infarct. The fungal infection was clinically silent otherwise, although fungal elements were also identified in the lung at autopsy. This case illustrates how closely fungal infection may resemble a leukemia-associated cerebrovascular accident.

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Authors and Affiliations

  1. SUNY Health Science Center, Syracuse NY, USA, , , , , , US

    S. C. Mathur

  2. Department of Pathology and Laboratory Medicine, Department of Veterans Affairs Medical Center and SUNY Health Science Center, Syracuse NY, USA, , , , , , US

    H. D. Friedman

  3. Gastroenterology Section, Armed Forces Institute of Pathology, Washington DC, USA, , , , , , US

    A. I. Kende

  4. Department of Pathology, State University of New York Health Science Center, Syracuse, NY, USA, , , , , , US

    R. L. Davis

  5. Division of Hematology and Oncology, Veterans Administration Medical Center and SUNY Health Science Center, Syracuse, NY, USA, , , , , , US

    S. L. Graziano

Authors
  1. S. C. Mathur
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  2. H. D. Friedman
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  3. A. I. Kende
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  4. R. L. Davis
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  5. S. L. Graziano
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Received: July 27, 1998 / Accepted: November 26, 1998

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Mathur, S., Friedman, H., Kende, A. et al. Cryptic Mucor infection leading to massive cerebral infarction at initiation of antileukemic chemotherapy. Ann Hematol 78, 241–245 (1999). https://doi.org/10.1007/s002770050509

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  • DOI: https://doi.org/10.1007/s002770050509

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