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Downbeat nystagmus caused by thiamine deficiency: an unusual presentation of CNS localization of large cell anaplastic CD 30-positive non-Hodgkin's lymphoma

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Abstract

 A 24-year-old woman with a large cell anaplastic CD 30-positive T-cell non-Hodgkin's lymphoma (NHL) developed downbeat nystagmus, anisocoria, and oscillopsia. Prior to overt cerebral invasion by NHL, she had a thiamine deficiency with very low thiamine concentrations in the CSF, probably caused by protracted vomiting and increased vitamin B1 consumption by intrathecal tumor cells. We believe that her neurologic symptoms were caused – at least partly – by thiamine deficiency, as she reacted well to thiamine supplementation at the beginning of treatment.

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Authors and Affiliations

  1. Department of Medicine, St. Joseph Hospital, Postbus 7777, 5500 MB Veldhoven, The Netherlands (Fax: 0031-40-2588246), , , , , , NL

    A. H. Mulder

  2. Department of Hematology, University Hospital Nijmegen, The Netherlands, , , , , , NL

    J. M. M. Raemaekers

  3. Department of Neurology, University Hospital Nijmegen, The Netherlands, , , , , , NL

    R. H. Boerman

  4. Department of Medicine, Rijnstate Hospital, Arnhem, The Netherlands, , , , , , NL

    V. Mattijssen

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  1. A. H. Mulder
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  2. J. M. M. Raemaekers
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  3. R. H. Boerman
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  4. V. Mattijssen
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Received: September 16, 1998 / Accepted: October 22, 1998

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Mulder, A., Raemaekers, J., Boerman, R. et al. Downbeat nystagmus caused by thiamine deficiency: an unusual presentation of CNS localization of large cell anaplastic CD 30-positive non-Hodgkin's lymphoma. Ann Hematol 78, 105–107 (1999). https://doi.org/10.1007/s002770050484

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  • DOI: https://doi.org/10.1007/s002770050484

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