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Morphologic and phenotypic changes of the leukemic cells in a case of marginal zone B-cell lymphoma

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Abstract

 A particular case of marginal zone B-cell lymphoma (MZBCL) presenting with leukemic lymphocytes is reported. In the present observation, the leukemic cells not only displayed a remarkable morphological fluctuation but also had an unusual phenotype, changing with time. These phenotypic features, which have been functionally investigated by in vitro assays, might simply reflect an activation state depending on the microenvironment. Because of its disconcerting similarities with hairy cell leukemia (HCL) and splenic lymphoma with villous lymphocytes (SLVL), this case relaunches the debate about whether close relationships might exist between the splenic marginal zone, SLVL and HCL.

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Authors and Affiliations

  1. Department of Pathology, Institut Jules Bordet, 1, Rue Héger-Bordet, B-1000 Brussels, Belgium, , , , , , BE

    J. L. Dargent

  2. Department of Immunology-Hematology, Erasme Hospital, Brussels, Belgium, , , , , , BE

    J. P. Delville, A. Kornreich, O. Pradier & P. Capel

  3. Department of Medical Genetics/I.R.I.B.H.N., Erasme Hospital, Brussels, Belgium, , , , , , BE

    P. Cochaux & T. Velu

  4. Department of Hematology-Oncology, Erasme Hospital, Brussels, Belgium, , , , , , BE

    W. Feremans & P. Neve

Authors
  1. J. L. Dargent
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  2. J. P. Delville
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  3. A. Kornreich
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  4. O. Pradier
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  5. P. Cochaux
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  6. T. Velu
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  7. P. Capel
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  8. W. Feremans
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  9. P. Neve
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Received: 3 September 1996 / Accepted: 22 November 1996

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Dargent, J., Delville, J., Kornreich, A. et al. Morphologic and phenotypic changes of the leukemic cells in a case of marginal zone B-cell lymphoma. Ann Hematol 74, 149–153 (1997). https://doi.org/10.1007/s002770050274

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  • DOI: https://doi.org/10.1007/s002770050274

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