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Interleukin-6 receptor expression in the peripheral B cells of patients with multicentric Castleman's disease

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Abstract

 Interleukin-6 (IL-6) is an important regulator of terminal B-cell differentiation. Inappropriate oversynthesis of IL-6 may play a primary role in the pathogenesis of multicentric Castleman's disease (MCD). We investigated the expression of the IL-6 receptor (IL-6R) in peripheral B cells from three patients with MCD, as well as the responsiveness of these cells to IL-6. Flow-cytometric analysis showed that IL-6R was significantly expressed on the peripheral B cells of two of three patients. The B cells expressing IL-6R spontaneously produced increased levels of immunoglobulin G (IgG). IL-6R-expressing B cells from one patient showed hyper-responsiveness to IL-6.

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Authors and Affiliations

  1. Department of Hematology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, 142 Tokyo, Japan, , , , , , JP

    T. Ishiyama, M. Koike, T. Kakimoto & N. Tsuruoka

  2. Divison of Clinical and Laboratory Science, Juntenodo University School of Medicine, , , , ,

    S. Nakamura

  3. I-I Hongo, Bunkyo-Ku, 113 Tokyo, Japan, , , , , , JP

    Y. Akimoto

Authors
  1. T. Ishiyama
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  2. M. Koike
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  3. S. Nakamura
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  4. T. Kakimoto
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  5. Y. Akimoto
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  6. N. Tsuruoka
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Received: 6 March 1996 / Accepted: 12 June 1996

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Ishiyama, T., Koike, M., Nakamura, S. et al. Interleukin-6 receptor expression in the peripheral B cells of patients with multicentric Castleman's disease. Ann Hematol 73, 179–182 (1996). https://doi.org/10.1007/s002770050224

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  • DOI: https://doi.org/10.1007/s002770050224

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