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A long-lasting, complete hematologic and cytogenetic remission of chronic myelogenous leukemia after treatment with busulfan alone

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Abstract

 A 44-year-old man suffering from cytogenetically and molecularly proven Philadelphia translocation-positive chronic myelogenous leukemia in chronic phase was treated with busulfan for 18 months and studied during a follow-up period of 13 years. Hematologically and cytogenetically, he attained a continuing complete remission, although at one point (9.5 years) at least, after attaining complete remission molecular analysis indicated the presence of minimal residual disease.

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Authors and Affiliations

  1. University Hospital Nijmegen, 544 Department of Hematology, P. O. Box 9101, NL-6500 HB Nijmegen, The Netherlands, , , , , , NL

    C. M. P. W. Mandigers, E. J. B. M. Mensink, C. Haanen & T. de Witte

  2. University Hospital Nijmegen, Department of Anthropogenetica, The Netherlands, , , , , , NL

    A. Geurts van Kessel

  3. Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands, , , , , , NL

    D. C. van der Plas & A. Hagemeÿer

Authors
  1. C. M. P. W. Mandigers
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  2. E. J. B. M. Mensink
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  3. A. Geurts van Kessel
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  4. D. C. van der Plas
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  5. C. Haanen
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  6. A. Hagemeÿer
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  7. T. de Witte
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Received: 27 October 1995 / Accepted: 27 February 1996

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Mandigers, C., Mensink, E., van Kessel, A. et al. A long-lasting, complete hematologic and cytogenetic remission of chronic myelogenous leukemia after treatment with busulfan alone. Ann Hematol 72, 371–373 (1996). https://doi.org/10.1007/s002770050188

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  • DOI: https://doi.org/10.1007/s002770050188

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