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Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature

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Abstract

 Acute Respiratory distress syndrome (ARDS) is a rare complication following intrathecal (IT) injection of methotrexate (MTX) in adult acute lymphoblastic leukemia (ALL) patients. A 19-year-old man with ALL developed strikingly acute respiratory failure during central nervous system (CNS) prophylaxis with IT MTX administration and cranial irradiation. Histopathologic study of the lungs revealed a pattern of diffuse alveolar damage with interstitial cellular infiltration. His symptoms were relieved soon following treatment with corticosteroids and the pulmonary infiltrates resolved gradually. Pulmonary symptoms did not recur as he was continuously treated with oral corticosteroids.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 8, Section 3, Ting-Chow Road, Taipei, Taiwan, Republic of China e-mail: tsuyi@ndmc1.ndmctsgh.edu.tw Tel.: +886-2-23685298 Fax: +886-2-23658544, , , , , , TW

    M. S. Dai, C. L. Ho, Y. C. Chen, W. Y. Kao & T. Y. Chao

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  1. M. S. Dai
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  2. C. L. Ho
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  3. Y. C. Chen
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  4. W. Y. Kao
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  5. T. Y. Chao
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Received: 31 January 2000 / Revised: 16 March 2000 / Accepted: 8 May 2000

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Dai, M., Ho, C., Chen, Y. et al. Acute respiratory distress syndrome following intrathecal methotrexate administration: a case report and review of literature. Ann Hematol 79, 696–699 (2000). https://doi.org/10.1007/s002770000217

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  • DOI: https://doi.org/10.1007/s002770000217

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