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Dry gangrene in a patient with sickle cell disease on hydroxyurea: a case report

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References

  1. Al Wahbi A (2018) Autoamputation of diabetic toe with dry gangrene: a myth or a fact? Diabetes Metab Syndr Obes 11:255–264. https://doi.org/10.2147/DMSO.S164199

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Kumar B, Saraswat A, Kaur I (2002) Mucocutaneous adverse effects of hydroxyurea: a prospective study of 30 psoriasis patients. Clin Exp Dermatol 27(1):8–13. https://doi.org/10.1046/j.0307-6938.2001.00947.x

    Article  CAS  PubMed  Google Scholar 

  3. Vassallo C, Passamonti F, Merante S, Ardigo M, Nolli G, Mangiacavalli S, Borroni G (2001) Muco-cutaneous changes during long-term therapy with hydroxyurea in chronic myeloid leukaemia. Clin Exp Dermatol 26(2):141–148. https://doi.org/10.1046/j.1365-2230.2001.00782.x

    Article  CAS  PubMed  Google Scholar 

  4. Best PJ, Daoud MS, Pittelkow MR, Petitt RM (1998) Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med 128(1):29–32. https://doi.org/10.7326/0003-4819-128-1-199801010-00005

    Article  CAS  PubMed  Google Scholar 

  5. Chaine B, Neonato MG, Girot R, Aractingi S (2001) Cutaneous adverse reactions to hydroxyurea in patients with sickle cell disease. Arch Dermatol 137(4):467–470

    CAS  PubMed  Google Scholar 

  6. Lanzkron S, Strouse JJ, Wilson R, Beach MC, Haywood C, Park H, Witkop C, Bass EB, Segal JB (2008) Systematic review: Hydroxyurea for the treatment of adults with sickle cell disease. Ann Intern Med 148(12):939–955. https://doi.org/10.7326/0003-4819-148-12-200806170-00221

    Article  PubMed  PubMed Central  Google Scholar 

  7. Leo E, Kramer A, Hochhaus A, Krasniqi F, Hehlmann R, Ho AD (2002) Gangrene of the toes in a patient with chronic myelogenous leukemia after long-term hydroxyurea therapy. Ann Hematol 81(8):467–469. https://doi.org/10.1007/s00277-002-0505-0

    Article  CAS  PubMed  Google Scholar 

  8. Yasuda N, Ohmori S, Usui T (2000) Hydroxyurea-induced gangrene of the toes in a patient with chronic myelogenous leukemia. Am J Hematol 63(2):103–104. https://doi.org/10.1002/(sici)1096-8652(200002)63:2%3C103::aid-ajh11%3E3.0.co;2-n

    Article  CAS  PubMed  Google Scholar 

  9. Montefusco E, Alimena G, Gastaldi R, Carlesimo OA, Valesini G, Mandelli F (1986) Unusual dermatologic toxicity of long-term therapy with hydroxyurea in chronic myelogenous leukemia. Tumori 72(3):317–321. https://doi.org/10.1177/030089168607200314

    Article  CAS  PubMed  Google Scholar 

  10. Monfort JB, Senet P (2020) Leg Ulcers in Sickle-Cell Disease: treatment update. Adv Wound Care (New Rochelle) 9(6):348–356. https://doi.org/10.1089/wound.2018.0918

    Article  PubMed  Google Scholar 

  11. Minniti CP, Kato GJ (2016) Critical reviews: how we treat sickle cell patients with leg ulcers. Am J Hematol 91(1):22–30. https://doi.org/10.1002/ajh.24134

    Article  PubMed  Google Scholar 

  12. Kranke P, Bennett MH, Martyn-St James M, Schnabel A, Debus SE, Weibel S (2015) Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev 2015(6):CD004123. https://doi.org/10.1002/14651858.CD004123.pub4

    Article  PubMed  PubMed Central  Google Scholar 

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Funding

This study was not funded.

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Authors and Affiliations

  1. Department of Medicine, University of Calgary, Calgary, AB, Canada

    Gurjeet Bhangu, Kelsey Uminski, Cameron Roessner, Dawn Goodyear, Trudy Sale & Natalia Rydz

  2. Southern Alberta Rare Blood and Bleeding Disorders Comprehensive Care Program, Calgary, AB, Canada

    Kelsey Uminski, Cameron Roessner, Dawn Goodyear, Trudy Sale & Natalia Rydz

  3. Division of Hematology & Hematological Malignancies, Room 681 Foothills Medical Centre, 1403 29th Street NW T2N 2T9, Calgary, AB, Canada

    Natalia Rydz

Authors
  1. Gurjeet Bhangu
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  2. Kelsey Uminski
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  3. Cameron Roessner
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  4. Dawn Goodyear
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  5. Trudy Sale
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  6. Natalia Rydz
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Contributions

Each author was involved in the writing of the manuscript. All authors approved the final manuscript.

Corresponding author

Correspondence to Natalia Rydz.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Written informed consent was obtained from the patient for the publication of this case report and accompanying images.

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The authors declare no competing interests.

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Bhangu, G., Uminski, K., Roessner, C. et al. Dry gangrene in a patient with sickle cell disease on hydroxyurea: a case report. Ann Hematol (2024). https://doi.org/10.1007/s00277-024-05732-w

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  • DOI: https://doi.org/10.1007/s00277-024-05732-w

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