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Acute liver injury after SARS-CoV-2 vaccination and luspatercept administration in a patient with β-thalassemia

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Fig. 1

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No datasets were generated or analysed during the current study.

References

  1. Codoni G, Kirchner T, Engel B, Villamil AM, Efe C, Stattermayer AF et al (2023) Histological and serological features of acute liver injury after SARS-CoV-2 vaccination. JHEP Rep 5(1):100605

    Article  PubMed  Google Scholar 

  2. Patel AH, Amin R, Lalos AT (2022) Acute liver injury and IgG4-related autoimmune pancreatitis following mRNA-based COVID-19 vaccination. Hepatol Forum 3(3):97–99

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Wong CKH, Mak LY, Au ICH, Lai FTT, Li X, Wan EYF et al (2022) Risk of acute liver injury following the mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccines. J Hepatol 77(5):1339–1348

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Efe C, Kulkarni AV, Terziroli Beretta-Piccoli B, Magro B, Stattermayer A, Cengiz M et al (2022) Liver injury after SARS-CoV-2 vaccination: features of immune-mediated hepatitis, role of corticosteroid therapy and outcome. Hepatology 76(6):1576–1586

    Article  CAS  PubMed  Google Scholar 

  5. Bril F, Al Diffalha S, Dean M, Fettig DM (2021) Autoimmune hepatitis developing after coronavirus disease 2019 (COVID-19) vaccine: causality or casualty? J Hepatol 75(1):222–224

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Kulkarni AV, Anders M, Nazal L, Ridruejo E, Efe C (2023) Cases of severe acute liver injury following inactivated SARS-CoV-2 vaccination. J Hepatol 78(2):e60–e61

    Article  CAS  PubMed  Google Scholar 

  7. Shroff H, Satapathy SK, Crawford JM, Todd NJ, VanWagner LB (2022) Liver injury following SARS-CoV-2 vaccination: a multicenter case series. J Hepatol 76(1):211–214

    Article  CAS  PubMed  Google Scholar 

  8. Cappellini MD, Viprakasit V, Taher AT, Georgiev P, Kuo KHM, Coates T et al (2020) A phase 3 trial of luspatercept in patients with transfusion-dependent β-thalassemia. N Engl J Med 382(13):1219–1231

    Article  CAS  PubMed  Google Scholar 

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Funding

The Italian Ministry of Health (RC − 2022/2023) supported this work.

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Authors and Affiliations

  1. University of Milan, Milan, Italy

    Simona Leoni

  2. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, SC Medicina Ad Indirizzo Metabolico, Milan, Italy

    Simona Leoni, Francesca Granata, Elena Cassinerio, Anna Ludovica Fracanzani, Maria Domenica Cappellini & Irene Motta

  3. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

    Rayan Bou-Fakhredin, Maria Domenica Cappellini & Irene Motta

  4. Department of Pathology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy

    Marco Maggioni

  5. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

    Anna Ludovica Fracanzani

Authors
  1. Simona Leoni
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  2. Rayan Bou-Fakhredin
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  3. Francesca Granata
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  4. Elena Cassinerio
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  5. Marco Maggioni
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  6. Anna Ludovica Fracanzani
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  7. Maria Domenica Cappellini
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  8. Irene Motta
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Contributions

S.L. collected data, performed research and wrote the original draft. R.B. analysed and interpreted the data and performed review and editing. M.M. performed histological diagnosis. F.G., E.C., A.L.F and M.D.C. performed review, and editing. I.M. critically reviewed and edited the manuscript and supervised the whole work. All authors approved the final manuscript.

Corresponding author

Correspondence to Irene Motta.

Ethics declarations

Informed consent

The patient gave informed consent.

Competing interests

M.D.C. has been or is a current consultant for Celgene Corp (Bristol Myers Squibb) and received research funding from Celgene Corp (Bristol Myers Squibb). I.M. has been or is a current consultant for Bristol Myers Squibb. S.L., R.B., F.G., E.C., M.M., and A.L.F declare no competing financial interests.

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Leoni, S., Bou-Fakhredin, R., Granata, F. et al. Acute liver injury after SARS-CoV-2 vaccination and luspatercept administration in a patient with β-thalassemia. Ann Hematol 103, 1025–1026 (2024). https://doi.org/10.1007/s00277-023-05591-x

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  • DOI: https://doi.org/10.1007/s00277-023-05591-x

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