Skip to main content

Advertisement

SpringerLink
Log in

Successful treatment with oseltamivir phosphate in children with ITP who failed first-line therapy: a case series report

  • Original Article
  • Published:
Annals of Hematology Aims and scope Submit manuscript

Abstract

Immune thrombocytopenia (ITP) is a common bleeding disorder in children. First-line medicines (glucocorticoids and immunoglobulin) may not be effective for some children, endangering their lives, posing challenges for healthcare facilities, and leading to an unfavorable prognosis. As a sialidase inhibitor, oseltamivir phosphate can reduce the destruction of platelets in liver macrophages by inhibiting the sialylation of platelets, and finally achieve the purpose of increasing platelet count. In this paper, three cases of children with ITP who failed first-line therapy and were cured by oral administration of oseltamivir phosphate granules were reported. The mechanism of action of oseltamivir phosphate granules was clarified.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Data availability

The datasets generated during and/or analyzed in the current study are available from the corresponding author on reasonable request.

References

  1. Alioglu B, Tasar A, Ozen C, Selver B, Dallar Y (2010) An experience of oseltamivir phosphate (tamifluM) in a pediatric patient with chronic idiopathic thrombocytopenic purpura: a case report. Pathophysiol Haemost Thromb 37(2–4):55–58. https://doi.org/10.1159/000321379

    Article  PubMed  Google Scholar 

  2. Shao L, Wu Y, Zhou H, Qin P, Ni H, Peng J, Hou M (2015) Successful treatment with oseltamivi r phosphate in a patient with chronic immune thrombocytopenia positive for anti-GPIb/IX autoanti body. Platelets 26(5):495–497. https://doi.org/10.3109/09537104.2014.948838

    Article  CAS  PubMed  Google Scholar 

  3. Revilla N, Corral J, Miñano A, Mingot-Castellano ME, Campos RM, Velasco F, Gonzalez N, Galvez E, Berrueco R, Fuentes I, Gonzalez-Lopez TJ, de la Morena-Barrio ME, Gonzalez-Porras JR, Vicente V, Lozano ML (2019) Multirefractory primary immune thrombocytopenia; Targeting the decreased sialic acid content. Platelets 30(6):743–751. https://doi.org/10.1080/09537104.2018.1513476

    Article  CAS  PubMed  Google Scholar 

  4. Shaim H, Mccaffrey P, Trieu JA, Deanda A, Yates SG (2020) Evaluating the effects of oseltamivir phosphate on platelet counts: a retrospective review. Platelets 31(8):1080–1084. https://doi.org/10.1080/09537104.2020.1714576

    Article  CAS  PubMed  Google Scholar 

  5. Sun L, Wang J, Shao L, Yuan C, Zhao H, Li D, Wang Z, Han P, Yu Y, Xu M, Zhao H, Qiu J, Zhou H, Liu X, Hou Y, Peng J, Hou M (2021) Dexamethasone plus oseltamivir versus dexamethas one in treatment-naive primary immune thrombocytopenia: a multicentre, randomised, open-label, phase 2 trial. Lancet Haematol 8(4):e289–e298. https://doi.org/10.1016/S2352-3026(21)00030-2

    Article  CAS  PubMed  Google Scholar 

  6. Hoffmeister KM, Falet H (2016) Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance. Thromb Res 141 Suppl 2(Suppl 2):S68-S72. https://doi.org/10.1016/S0049-3848(16)30370-X

  7. Quach ME, Dragovich MA, Chen W, Syed AK, Cao W, Liang X, Deng W, De Meyer SF, Zhu G, Peng J, Ni H, Bennett CM, Hou M, Ware J, Deckmyn H, Zhang XF, Li R (2018) Fc-independen t immune thrombocytopenia via mechanomolecular signaling in platelets. Blood 131(7):787–796. https://doi.org/10.1182/blood-2017-05-784975

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Mcmillan R (2007) The pathogenesis of chronic immune thrombocytopenic purpura. Semin Hematol 44(4 Suppl 5):S3-S11. https://doi.org/10.1053/j.seminhematol.2007.11.002

  9. Deppermann C, Kratofil RM, Peiseler M, David BA, Zindel J, Castanheira F, van der Wal F, Carestia A, Jenne CN, Marth JD, Kubes P (2020) Macrophage galactose lectin is critical for Kupffer ce lls to clear aged platelets. J Exp Med 217(4):e20190723. https://doi.org/10.1084/jem.20190723

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Li J, van der Wal DE, Zhu G, Xu M, Yougbare I, Ma L, Vadasz B, Carrim N, Grozovsky R, Ruan M, Zhu L, Zeng Q, Tao L, Zhai ZM, Peng J, Hou M, Leytin V, Freedman J, Hoffmeister KM, Ni H (2015) Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia. Nat Commun 6:7737. https://doi.org/10.1038/ncomms8737

    Article  CAS  PubMed  Google Scholar 

  11. Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH (2003) The clearance mechanism of chilled blood platelets. Cell 112(1):87–97. https://doi.org/10.1016/s0092-8674(02)01253-9

    Article  CAS  PubMed  Google Scholar 

  12. Tao L, Zeng Q, Li J, Xu M, Wang J, Pan Y, Wang H, Tao Q, Chen Y, Peng J, Hou M, Jansen AJ, Ni H, Zhai Z (2017) Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia. J Hematol Oncol 10(1):46. https://doi.org/10.1186/s13045-017-0413-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Marini I, Zlamal J, Faul C, Holzer U, Hammer S, Pelzl L, Bethge W, Althaus K, Bakchoul T (2021) Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan. Haematologica 106(1):196–207. https://doi.org/10.3324/haematol.2019.236117

    Article  CAS  PubMed  Google Scholar 

  14. Zheng SS, Ahmadi Z, Leung HHL, Wong R, Yan F, Perdomo JS (2022) Chong BH (2022) Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia. Haematol- Hematol J 107(9):2195–2205. https://doi.org/10.3324/haematol.2021.279751

    Article  CAS  Google Scholar 

  15. Tamiflu® US Prescribing Information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021087s068,021246s051lbl.pdf. Accessed February 02, 2021.

Download references

Acknowledgements

The authors would like to thank EssentialsLink Language Services (http://www.essentialslink.cn) for its linguistic assistance during the preparation of this manuscript.

Funding

This research was supported by the excellent teaching case project of professional degree graduate students in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine (Grant No.YJSJPAL-202216). The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Author information

Authors and Affiliations

  1. The First Affiliated Hospital of Henan University of Chinese Medicine, Henan, China

    Li-ya Liu, Bo Zhang, Chun-dong Song, Peng-fei Li, Meng Yang, Xian-qing Ren & Ying Ding

  2. School of Pediatrics, Henan University of Chinese Medicine, Henan, China

    Li-ya Liu, Bo Zhang, Chun-dong Song, Peng-fei Li, Meng Yang, Xian-qing Ren & Ying Ding

Authors
  1. Li-ya Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bo Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chun-dong Song
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peng-fei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Meng Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xian-qing Ren
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ying Ding
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

LL and BZ took care of the patient; PL and MY performed the clinical data analysis; LL wrote the manuscript; CS reviewed and edited the manuscript; XR and YD supervised the project.

Corresponding author

Correspondence to Ying Ding.

Ethics declarations

Ethics approval

The treatment plan has been approved by the Ethics Committee of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine.

Consent to participate

Written informed consent was obtained from the patients to use the content and imaging material for publication.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, Ly., Zhang, B., Song, Cd. et al. Successful treatment with oseltamivir phosphate in children with ITP who failed first-line therapy: a case series report. Ann Hematol 103, 405–408 (2024). https://doi.org/10.1007/s00277-023-05581-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-023-05581-z

Keywords

Search

Navigation