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Allogeneic hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia

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Abstract

This study was aimed to explore the prognosis of allogenic hematopoietic stem cell transplantation (allo-HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL). This retrospective case series study included children with ALL who underwent allo-HSCT at Beijing Children’s Hospital of Capital Medical University, Beijing, China, between January 2009 and December 2019. The outcomes included 5-year overall survival (OS) and event-free survival (EFS). A total of 75 children (52 males) were included. The median age at presentation was 5.30 years, and the median time from diagnosis to transplantation was 1.64 years. There were 15 human leukocyte antigen (HLA)-matched and 60 HLA-semi-matched transplants, 73 complete remissions (CR), and 2 MRD-positive transplants. The median follow-up time was 41 months. Out of 75 patients, 51 children survived, and 24 died/given up at the terminal stage. The 5-year OS and EFS rates were 67.77% and 57.30%, respectively, whereas the 5-year recurrence rate was 35.69%. Acute and chronic graft versus host diseases occurred in 40 and 28 cases, respectively. Children with MLL gene fusion had higher survival rates compared to other subgroups. Haplo-HSCT is not inferior to HLA-matched transplant. The children with MLL rearrangement had an acceptable 5-year OS, while complications and relapse should be monitored.

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Funding

This study was supported by the National Science and Technology Major Project (2017ZX09304029004).

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Author notes

  1. Jieyu Tian and Ang Wei are co-first authors for this study.

Authors and Affiliations

  1. Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

    Jieyu Tian, Ang Wei, Bin Wang, Jun Yang, Huyong Zheng & Maoquan Qin

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  1. Jieyu Tian
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  2. Ang Wei
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  6. Maoquan Qin
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Corresponding author

Correspondence to Maoquan Qin.

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The study was carried out in accordance with the Declaration of Helsinki, approved by the Ethics Review Committee of Beijing Children’s Hospital, Capital Medical University, Beijing, China.

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This study was exempted from patient informed consent.

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Tian, J., Wei, A., Wang, B. et al. Allogeneic hematopoietic stem cell transplantation for pediatric acute lymphoblastic leukemia. Ann Hematol 103, 297–305 (2024). https://doi.org/10.1007/s00277-023-05506-w

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  • DOI: https://doi.org/10.1007/s00277-023-05506-w

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