References
Chari A, Samur MK, Martinez-Lopez J, Cook G, Biran N, Yong K, Hungria V, Engelhardt M, Gay F, García Feria A, Oliva S, Oostvogels R, Gozzetti A, Rosenbaum C, Kumar S, Stadtmauer EA, Einsele H, Beksac M, Weisel K et al (2020) Clinical features associated with COVID-19 outcome in multiple myeloma: first results from the International Myeloma Society data set. Blood 136(26):3033–3040. https://doi.org/10.1182/blood.2020008150
Ludwig H, Sonneveld P, Facon T, San-Miguel J, Avet-Loiseau H, Mohty M, Mateos MV, Moreau P, Cavo M, Pawlyn C, Zweegman S, Engelhardt M, Driessen C, Cook G, Dimopoulos MA, Gay F, Einsele H, Delforge M, Caers J et al (2021) COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network. Lancet Haematol 8(12):e934–e946. https://doi.org/10.1016/S2352-3026(21)00278-7
Chuleerarux N, Manothummetha K, Moonla C, Sanguankeo A, Kates OS, Hirankarn N, Phongkhun K, Thanakitcharu J, Leksuwankun S, Meejun T, Thongkam A, Mongkolkaew T, Dioverti MV, Torvorapanit P, Langsiri N, Worasilchai N, Plongla R, Chindamporn A, Gopinath S et al (2022) Immunogenicity of SARS-CoV-2 vaccines in patients with multiple myeloma: a systematic review and meta-analysis. Blood Adv 6(24):6198–6207. https://doi.org/10.1182/bloodadvances.2022008530
Van Oekelen O, Gleason CR, Agte S, Srivastava K, Beach KF, Aleman A, Kappes K, PVI/Seronet team, Mouhieddine TH, Wang B, Chari A, Cordon-Cardo C, Krammer F, Jagannath S, Simon V, Wajnberg A, Parekh S (2021) Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma. Cancer Cell 39(8):1028–1030. https://doi.org/10.1016/j.ccell.2021.06.014
Nooka AK, Shanmugasundaram U, Cheedarla N, Verkerke H, Edara VV, Valanparambil R, Kaufman JL, Hofmeister CC, Joseph NS, Lonial S, Azeem M, Manalo J, Switchenko JM, Chang A, Linderman SL, Roback JD, Dhodapkar KM, Ahmed R, Suthar MS et al (2022) Determinants of neutralizing antibody response after SARS CoV-2 vaccination in patients with myeloma. J Clin Oncol 40(26):3057–3064. https://doi.org/10.1200/JCO.21.02257
Faustini SE, Hall A, Brown S, Roberts S, Hill H, Stamataki Z, (PITCH) consortium, Jenner MW, Owen RG, Pratt G, Cook G, Richter A, Drayson MT, Kaiser MF, JLJ H (2023) Immune responses to COVID-19 booster vaccinations in intensively anti-CD38 antibody treated patients with ultra-high-risk multiple myeloma: results from the Myeloma UK (MUK) nine OPTIMUM trial. Br J Haematol 201(5):845–850. https://doi.org/10.1111/bjh.18714
Aleman A, Van Oekelen O, Upadhyaya B, Beach K, Kogan Zajdman A, Alshammary H, Serebryakova K, Agte S, Kappes K, Gleason CR, Srivastava K, PVI/MM/Seronet Study Group, Almo S, Cordon-Cardo C, Krammer F, Merad M, Jagannath S, Wajnberg A, Simon V, Parekh S (2022) Augmentation of humoral and cellular immune responses after third-dose SARS-CoV-2 vaccination and viral neutralization in myeloma patients. Cancer Cell 40(5):441–443. https://doi.org/10.1016/j.ccell.2022.03.013
Ntanasis-Stathopoulos I, Karalis V, Gavriatopoulou M, Malandrakis P, Sklirou AD, Eleutherakis-Papaiakovou E, Migkou M, Roussou M, Fotiou D, Alexopoulos H, Theodorakakou F, Kastritis E, Iconomidou VA, Trougakos IP, Dimopoulos MA, Terpos E (2022) Second booster BNT162b2 restores SARS-CoV-2 humoral response in patients with multiple myeloma, excluding those under anti-BCMA therapy. Hemasphere 6(8):e764. https://doi.org/10.1097/HS9.0000000000000764
Salmanton-García J, Marchesi F, Glenthøj A, Bilgin YM, van Praet J, Dávila-Valls J, Martín-Pérez S, Labrador J, van Doesum J, Falces-Romero I, Farina F, Schönlein M, Chanut M, Petzer V, Espigado I, Dargenio M, Aujayeb A, Sili U, Serrano L et al (2022) Improved clinical outcome of COVID-19 in hematologic malignancy patients receiving a fourth dose of anti-SARS-CoV-2 vaccine: an EPICOVIDEHA report. Hemasphere 6(11):e789. https://doi.org/10.1097/HS9.0000000000000789
Suribhatla R, Starkey T, Ionescu MC, Pagliuca A, Richter A, Lee LYW (2023) Systematic review and meta-analysis of the clinical effectiveness of tixagevimab/cilgavimab for prophylaxis of COVID-19 in immunocompromised patients. Br J Haematol 201(5):813–823. https://doi.org/10.1111/bjh.18782
Terpos E, Musto P, Engelhardt M, Delforge M, Cook G, Gay F, van de Donk NWCJ, Ntanasis-Stathopoulos I, Vangsted AJ, Driessen C, Schjesvold F, Cerchione C, Zweegman S, Hajek R, Moreau P, Einsele H, San-Miguel J, Boccadoro M, Dimopoulos MA et al (2023) Management of patients with multiple myeloma and COVID-19 in the post pandemic era: a consensus paper from the European Myeloma Network (EMN). Leukemia 37(6):1175–1185. https://doi.org/10.1038/s41375-023-01920-1
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PM and NS conceived and led the project; NS conducted database building, extraction, and coding; NS queried and analyzed the data; PM and NS wrote the main manuscript text and created table. All authors made a substantial intellectual contribution to the study, interpreted the data, discussed the results, and reviewed and approved the final version of the manuscript.
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Sgherza, N., Curci, P., Rizzi, R. et al. Clinical outcome of breakthrough COVID-19 in multiple myeloma patients after three or more anti-SARS-CoV-2 vaccine doses: a single center analysis of 64 cases. Ann Hematol 103, 351–355 (2024). https://doi.org/10.1007/s00277-023-05484-z
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DOI: https://doi.org/10.1007/s00277-023-05484-z