References
Fakhri B, Ai W (2021) Current and emerging treatment options in primary mediastinal B-cell lymphoma. Ther Adv Hematol 12:20406207211048960. https://doi.org/10.1177/20406207211048959
Roemer MG, Advani RH, Ligon AH, Natkunam Y, Redd RA, Homer H, Connelly CF, Sun HH, Daadi SE, Freeman GJ, Armand P, Chapuy B, de Jong D, Hoppe RT, Neuberg DS, Rodig SJ, Shipp MA (2016) PD-L1 and PD-L2 genetic alterations define classical hodgkin lymphoma and predict outcome. J Clin Oncol 34(23):2690–2697. https://doi.org/10.1200/JCO.2016.66.4482
Voorhees TJ, Beaven AW (2020) Therapeutic updates for relapsed and refractory classical hodgkin lymphoma. Cancers (Basel) 12(10):2887. https://doi.org/10.3390/cancers12102887
Collins GP, Parker AN, Pocock C, Kayani I, Sureda A, Illidge T, Ardeshna K, Linch DC, Peggs KS; British Committee for Standards in Haematology; British Society of Blood and Marrow Transplantation (2014) Guideline on the management of primary resistant and relapsed classical Hodgkin lymphoma. Br J Haematol 164(1):39–52. https://doi.org/10.1111/bjh.12582
Chen R, Zinzani PL, Fanale MA, Armand P, Johnson NA, Brice P, Radford J, Ribrag V, Molin D, Vassilakopoulos TP, Tomita A, von Tresckow B, Shipp MA, Zhang Y, Ricart AD, Balakumaran A, Moskowitz CH; KEYNOTE-087 (2017) Phase II Study of the Efficacy and Safety of Pembrolizumab for Relapsed/Refractory Classic Hodgkin Lymphoma. J Clin Oncol 35(19):2125–2132. https://doi.org/10.1200/JCO.2016.72.1316
Zinzani PL, Thieblemont C, Melnichenko V, Bouabdallah K, Walewski J, Majlis A, Fogliatto L, Garcia-Sancho AM, Christian B, Gulbas Z, Özcan M, Perini GF, Ghesquieres H, Shipp MA, Thompson S, Chakraborty S, Marinello P, Armand P (2023) Pembrolizumab in relapsed or refractory primary mediastinal large B-cell lymphoma: final analysis of KEYNOTE-170. Blood 142(2):141–145
Moskowitz AJ, Shah G, Schöder H, Ganesan N, Drill E, Hancock H, Davey T, Perez L, Ryu S, Sohail S, Santarosa A, Galasso N, Neuman R, Liotta B, Blouin W, Kumar A, Lahoud O, Batlevi CL, Hamlin P, Straus DJ, Rodriguez-Rivera I, Owens C, Caron P, Intlekofer AM, Hamilton A, Horwitz SM, Falchi L, Joffe E, Johnson W, Lee C, Palomba ML, Noy A, Matasar MJ, Pongas G, Salles G, Vardhana S, Sanin BW, von Keudell G, Yahalom J, Dogan A, Zelenetz AD, Moskowitz CH (2021) Phase II trial of pembrolizumab plus gemcitabine, vinorelbine, and liposomal doxorubicin as second-line therapy for relapsed or refractory classical hodgkin lymphoma. J Clin Oncol 39(28):3109–3117. https://doi.org/10.1200/JCO.21.01056
Jiang M, Hu Y, Lin G, Chen C (2022) Dosing Regimens of immune checkpoint inhibitors: attempts at lower dose, less frequency, shorter course. Front Oncol 12:906251. https://doi.org/10.3389/fonc.2022.906251
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Novelty statement
Low fixed dose pembrolizumab with GVD(Pembro100-GVD) is an effective, affordable chemo-immunotherapeutic salvage regimen for rrHL and rrPMBCL.
Specific clinical relevance
Limited cycles of low dose pembrolizumab based salvage therapies can be an effective regimen as bridge to transplant in rrHL and rrPMBCL.
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Panda, T., Rainchwar, S., Halder, R. et al. Low fixed dose pembrolizumab with gemcitabine, vinorelbine, liposomal doxorubicin (Pembro100 -GVD) as an effective salvage regimen in relapsed refractory classical hodgkin’s lymphoma and primary mediastinal B cell lymphoma. Ann Hematol 103, 347–349 (2024). https://doi.org/10.1007/s00277-023-05470-5
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DOI: https://doi.org/10.1007/s00277-023-05470-5