Skip to main content
Log in

Pegaspargase, venetoclax, and nelarabine: a successful bridge to allogeneic hematopoietic stem cell transplantation in a relapsed/refractory T-cell acute lymphoblastic leukemia patient

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Data availability

The data that support the findings of this study are available on request from the corresponding author.

References

  1. Marks DI, Rowntree C (2017) Management of adults with T-cell lymphoblastic leukemia. Blood 129(9):1134–1142

    Article  CAS  PubMed  Google Scholar 

  2. Wan CL, Zou JY, Qiao M et al (2021) Venetoclax combined with azacitidine as an effective and safe salvage regimen for relapsed or refractory T-cell acute lymphoblastic leukemia: a case series. Leuk Lymphoma 62(13):3300–3303

    Article  PubMed  Google Scholar 

  3. Candoni A, Lazzarotto D, Ferrara F et al (2020) Nelarabine as salvage therapy and bridge to allogeneic stem cell transplant in 118 adult patients with relapsed/refractory T-cell acute lymphoblastic leukemia/lymphoma. A CAMPUS ALL study. Am J Hematol 95(12):1466–1472

    Article  CAS  PubMed  Google Scholar 

  4. Baek DW, Lee JM, Kim J et al (2021) Therapeutic strategies, including allogeneic stem cell transplantation, to overcome relapsed/refractory adult T-cell acute lymphoblastic leukemia. Expert Rev Hematol 14(8):765–775

    Article  CAS  PubMed  Google Scholar 

  5. Richard-Carpentier G, Jabbour E, Short NJ et al (2020) Clinical experience with venetoclax combined with chemotherapy for relapsed or refractory T-cell acute lymphoblastic leukemia. Clin Lymphoma Myeloma Leuk 20(4):212–218

    Article  PubMed  Google Scholar 

  6. Farhadfar N, Li Y, May WS et al (2021) Venetoclax and decitabine for treatment of relapsed T-cell acute lymphoblastic leukemia: a case report and review of literature. Hematol Oncol Stem Cell Ther 14(3):246–251

    Article  PubMed  Google Scholar 

  7. McEwan A, Pitiyarachchi O, Viiala N (2020) Relapsed/refractory ETP-ALL successfully treated with venetoclax and nelarabine as a bridge to allogeneic stem cell transplant. HemaSphere 4(3):e379

    Article  PubMed  PubMed Central  Google Scholar 

  8. Candoni A, Lazzarotto D, Petruzzellis G (2021) Safety of nelarabine in adults with relapsed or refractory T-cell acute lymphoblastic leukemia/lymphoma. Expert Opin Drug Saf 20(7):751–756

    Article  CAS  PubMed  Google Scholar 

  9. Kathpalia M, Mishra P, Bajpai R et al (2022) Efficacy and safety of nelarabine in patients with relapsed or refractory T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis. Ann Hematol 101(8):1655–2166

    Article  CAS  PubMed  Google Scholar 

  10. Heo YA, Syed YY, Keam SJ (2019) Pegaspargase: a review in acute lymphoblastic leukaemia. Drugs 79(7):767–777

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Süreyya Yiğit Kaya.

Ethics declarations

Ethics approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent for publication was obtained from the patient. All the authors have reviewed the manuscript and approved it for publication.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yiğit Kaya, S., Bektas, S., Askin, A.E. et al. Pegaspargase, venetoclax, and nelarabine: a successful bridge to allogeneic hematopoietic stem cell transplantation in a relapsed/refractory T-cell acute lymphoblastic leukemia patient. Ann Hematol 102, 1599–1600 (2023). https://doi.org/10.1007/s00277-023-05231-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-023-05231-4

Navigation