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Impact of antithymocyte globulin on blood cyclosporin A levels in aplastic anemia patients

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Data Availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Abbreviations

AA:

Aplastic anemia

CsA:

Cyclosporin A

ACMIA:

Antibody-conjugated magnetic immunoassay

ATG:

Antithymocyte globulin

References

  1. Peslak SA, Olson T, Babushok DV (2017) Diagnosis and Treatment of Aplastic Anemia. Curr Treat Options Oncol 18:1–20. https://doi.org/10.1007/s11864-017-0511-z

    Article  Google Scholar 

  2. Zhang Y, Zhang R (2018) Recent advances in analytical methods for the therapeutic drug monitoring of immunosuppressive drugs. Drug Test Anal 10:81–94. https://doi.org/10.1002/dta.2290

    Article  CAS  Google Scholar 

  3. Lindholm A (1991) Factors Influencing the Pharmacokinetics of Cyclosporine in Man. Ther Drug Monit 13:465–477. https://doi.org/10.1097/00007691-199111000-00001

    Article  CAS  Google Scholar 

  4. Machishima T, Kako S, Wada H, Yamasaki R, Ishihara Y, Kawamura K, Sakamoto K, Sato M, Ashizawa M, Terasako K, Ichikimura S, Kikuchi M, Nakasone H, Kanda J, Yamazaki R, Nishida J, Kanda Y (2013) The safety and efficacy of acute graft-versus-host disease prophylaxis with a higher target blood concentration of cyclosporine around 500 ng/mL. Clin Transplant. 27:749–756. https://doi.org/10.1111/ctr.12213

    Article  CAS  Google Scholar 

  5. Lempers VJC, Martial LC, Schreuder MF, Blijlevens NM, Burger DM, Aarnoutse RE, Brüggemann RJM (2015) Drug-interactions of azole antifungals with selected immunosuppressants in transplant patients: strategies for optimal management in clinical practice. Curr Opin Pharmacol 24:38–44. https://doi.org/10.1016/j.coph.2015.07.002

    Article  CAS  Google Scholar 

  6. Ahn S, Cho J, Il Kim S, Yim J, Lee S-G, Kim J-H (2016) Characterization of circulating antibodies with affinity to an epitope used in antibody-conjugated magnetic immunoassays from a case of falsely elevated cyclosporine A. Clin Chim Acta 458:35–39. https://doi.org/10.1016/j.cca.2016.04.021

    Article  CAS  Google Scholar 

  7. Morelle J, Wallemacq P, Van Caeneghem O, Goffin E (2011) Clinically unexpected cyclosporine levels using the ACMIA method on the RXL dimension analyser. Nephrol Dial Transplant 26:1428–1431. https://doi.org/10.1093/ndt/gfr002

    Article  CAS  Google Scholar 

  8. Peter A, Shipkova M, Wieland E, Schleicher E, Müller I (2011) Increased cyclosporine concentrations in the absence of cyclosporine administration. Clin Chem 57:670–673. https://doi.org/10.1373/clinchem.2010.148718

    Article  CAS  Google Scholar 

  9. Feng X, Scheinberg P, Biancotto A, Rios O, Donaldson S, Wu C, Zheng H, Sato K, Townsley DM, McCoy JP, Young NS (2014) In vivo effects of horse and rabbit antithymocyte globulin in patients with severe aplastic anemia. Haematologica 99:1433–1440. https://doi.org/10.3324/haematol.2014.106542

    Article  CAS  Google Scholar 

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Acknowledgements

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

Authors

Contributions

YF designed the study, collected and analyzed data, and wrote the first draft of the manuscript. Y Suga conceived and designed the study and contributed to the writing of the manuscript. TS and Y Sai supervised the project and contributed to the writing of the manuscript. All authors reviewed the results and approved the final version of the manuscript.

Corresponding author

Correspondence to Yuya Futagi.

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Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

The need for informed consent was waived by the board since this study is an observational study.

Conflict of interest

The authors declare that they have no conflict of interest.

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Futagi, Y., Suga, Y., Shimada, T. et al. Impact of antithymocyte globulin on blood cyclosporin A levels in aplastic anemia patients. Ann Hematol 102, 463–465 (2023). https://doi.org/10.1007/s00277-022-05063-8

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  • DOI: https://doi.org/10.1007/s00277-022-05063-8

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