Skip to main content

A novel WNK1::PDGFRB fusion gene in myeloid neoplasm with eosinophilia: a case report

This is a preview of subscription content, access via your institution.

Fig. 1

Data availability

Data sharing is not applicable to this article as no datasets were generated or analyzed.


  1. Arber DA, Orazi A, Hasserjian R, et al. (2016)The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405. Blood year 128 462-463.

  2. Dispenza MC, Bochner BS (2018) Diagnosis and novel approaches to the treatment of hypereosinophilic syndromes. Curr Hematol Malig Rep year 13:191–201.

    Article  Google Scholar 

  3. Di Giacomo D, Quintini M, Pierini V et al (2022) Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement. Ann Hematol year 101:297–307.

    CAS  Article  Google Scholar 

  4. Erben P, Gosenca D, Muller MC et al (2010) Screening for diverse PDGFRA or PDGFRB fusion genes is facilitated by generic quantitative reverse transcriptase polymerase chain reaction analysis. Haematologica year 95:738–744.

    CAS  Article  Google Scholar 

  5. Xu X, Lu Q, Wang Z et al (2021) Identification of a Novel CSNK2A1-PDGFRB fusion gene in a patient with myeloid neoplasm with eosinophilia. Cancer Res Treat 53:889–892.

    Article  PubMed  Google Scholar 

Download references


Thanks to Professor Chen Suning and Director Shen Hongjie of the First Affiliated Hospital of Soosuzhou University for their theoretical guidance and technical support.


This research was supported by the Ningbo and Yinzhou District Social and Development project (20191JCGY020007), China.

Author information

Authors and Affiliations



T.T.W and Y.L. were the principal investigators who took primary responsibility for this study. T.T.W wrote the manuscript. R.Z.P., X.H. L, and J.J.C studied and commented on the manuscript. Q.Q.L and M.W performed experiments and participated in clinical data management. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Renzhi Pei or Ying Lu.

Ethics declarations

Ethics approved this study was conducted in accordance with the principles of the Declaration of Helsinki and approved by the ethics committee of the institution. Informed consent was obtained from this patient.


Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wang, T., Cao, J., Lin, Q. et al. A novel WNK1::PDGFRB fusion gene in myeloid neoplasm with eosinophilia: a case report. Ann Hematol (2022).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: