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Rapid and deep response to avapritinib in heavily treated acute myeloid leukemia with t (8;21) and KIT mutation

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Fig. 1

Data availability

The data supporting this study’s findings are available from the corresponding author upon reasonable request.

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Funding

This study was funded by the grant from the National Key R&D Program of China (2019YFA0111000), the National Natural Science Foundation of China (81900130, 81970136, 81970142, 82000132, 8217011130, 8210010924), the Natural Science Foundation of the Jiangsu Higher Education Institution of China (18KJA320005), the Natural Science Foundation of Jiangsu Province (BK20190180), priority academic program development of Jiangsu Higher Education Institution, the Innovation Capability Development Project of Jiangsu Province (BM215004), the Translational Research Grant of NCRCH (2020WSB03, 2020WSB11, 2020WSB13), and the Open Project of Jiangsu Biobank of Clinical Resources (SBK202003001, SBK202003003).

Author information

Authors and Affiliations

  1. National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Suzhou, 215006, China

    Jia Yin, Feng Zhu, Zhi-Bo Zhang, Qian Wang, Xue-Feng He, Qian Wu, Jing-Ren Zhang, Ai-Ning Sun, De-Pei Wu, Xiao-Fei Yang & Su-Ning Chen

  2. Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China

    Jia Yin, Zhi-Bo Zhang, Xue-Feng He, Qian Wu, Jing-Ren Zhang, Ai-Ning Sun, De-Pei Wu, Xiao-Fei Yang & Su-Ning Chen

Authors
  1. Jia Yin
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  2. Feng Zhu
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  3. Zhi-Bo Zhang
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  4. Qian Wang
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  5. Xue-Feng He
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  6. Qian Wu
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  7. Jing-Ren Zhang
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  8. Ai-Ning Sun
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  9. De-Pei Wu
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  10. Xiao-Fei Yang
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  11. Su-Ning Chen
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Contributions

Jia Yin collected and analyzed data and wrote the first draft of the manuscript; Feng Zhu and Zhi-Bo Zhang collected the data and edited the paper; Qian Wang, Xue-Feng He, Qian Wu, and Jing-Ren Zhang provided patient care; Ai-Ning Sun, De-Pei Wu, Xiao-Fei Yang, and Su-Ning Chen designed research, analyzed data, and wrote the manuscript. The submission has been read and approved for submission by all authors.

Corresponding authors

Correspondence to Xiao-Fei Yang or Su-Ning Chen.

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Ethics approval

This case study has completely complied with the human research regulations and ethical requirements issued by the Ethics Committee of the First Affiliated Hospital of Soochow University.

Conflict of interest

The authors declare no competing interests.

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Jia Yin, Feng Zhu, and Zhi-Bo Zhang are co-first authors.

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Yin, J., Zhu, F., Zhang, ZB. et al. Rapid and deep response to avapritinib in heavily treated acute myeloid leukemia with t (8;21) and KIT mutation. Ann Hematol 101, 2347–2350 (2022). https://doi.org/10.1007/s00277-022-04897-6

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  • DOI: https://doi.org/10.1007/s00277-022-04897-6

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