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The value of prognostic nutritional index in nasal-type, extranodal natural killer/T-cell lymphoma

Annals of Hematology volume 101, pages 1545–1556 (2022)Cite this article

Abstract

Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive disorder with heterogeneous clinical characteristics and poor prognosis. The combined value of baseline serum albumin level and absolute peripheral lymphocyte count showed prognostic information in a variety of malignancies, but its evidence is limited in ENKTL. The purpose of this study is to evaluate the impact of prognostic nutritional index (PNI) in ENKTL, and to provide some nutritionally and immunologically relevant information for better risk stratification. We conducted a retrospective study in 533 patients newly diagnosed with ENKTL. The PNI was calculated as albumin (g/L) + 5 × lymphocyte count (109/L). The optimal cutoff values for serum albumin and lymphocyte count were 40.6 g/L and 1.18 × 109/L, respectively, and 47.3 for PNI. After a median follow-up of 70 months, the 5-year overall survival (OS) and progression-free survival (PFS) were 56.2% and 49.5%, respectively. Patients in low PNI group had more unfavorable clinical features, and tended to have worse 5-year OS and PFS compared with those in high PNI group. According PNI-associated prognostic score, patients were classified into different risk groups. Significant difference has been found in 5-year OS and PFS in different risk groups. When PNI and PNI-associated prognostic score were superimposed on the International Prognostic Index (IPI), prognostic index of natural killer lymphoma (PINK), or nomogram-revised risk index (NRI) categories, the PNI and PNI-associated prognostic score provided additional prognostic information. Therefore, PNI and PNI-associated prognostic score could be independent prognostic factors for ENKTL and may be useful for risk stratification and clinical decision-making.

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Data availability

The original data involved in this research will be made practicable by the authors on reasonable requirement, without excessive reservation.

Code availability

SPSS version 26.0 software (IBM SPSS) and R software (version 4.0.5).

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Authors and Affiliations

  1. Department of Medical Oncology of Cancer Center, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, China

    Na Li, Ming Jiang, Wan-chun Wu & Li-qun Zou

  2. Department of Oncology, West China Fourth Hospital, West China School of Public Health, Sichuan University, Chengdu, China

    Na Li

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  1. Na Li
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  2. Ming Jiang
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  4. Li-qun Zou
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Contributions

LQZ constructed this work and revised the manuscript. NL collected and analyzed data, performed research, and wrote the paper. MJ provided valuable recommendations. WCW participated in data analysis. All authors read and approved the final manuscript and the submitted version. All authors agreed both to be personally accountable for the author’s own contributions and to ensure that questions related to the accuracy or integrity of any part of the work.

Corresponding author

Correspondence to Li-qun Zou.

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Ethics approval

All data included in this study were approved by Ethics Committee on Biomedical Research, West China Hospital of Sichuan University, and in accordance with the declaration of Helsinki.

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Informed consent was exempted for this was a retrospective study.

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The authors declare no competing interests.

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Highlights

PNI and PNI-associated prognostic score predicted prognosis in ENKTL; when these factors were applied to IPI, PINK, and NRI models, better results were found.

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Li, N., Jiang, M., Wu, Wc. et al. The value of prognostic nutritional index in nasal-type, extranodal natural killer/T-cell lymphoma. Ann Hematol 101, 1545–1556 (2022). https://doi.org/10.1007/s00277-022-04849-0

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  • DOI: https://doi.org/10.1007/s00277-022-04849-0

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