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Potential risk factors for the development from immune thrombocytopenia to systemic lupus erythematosus: a case–control study in Chinese children

Annals of Hematology volume 101, pages 1447–1456 (2022)Cite this article

A Correction to this article was published on 24 May 2022

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Abstract

Immune thrombocytopenia (ITP) patients are at risk developing to systemic lupus erythematosus (SLE) in the future. Our study attempted to explore the potential risk factors for the development from ITP to SLE in Chinese children by statistical analysis. This study was a retrospective case–control study. Patients diagnosed with ITP and developed to SLE after the diagnosis of ITP were defined as the case group. The control group consisted of children with ITP but without developing to SLE was recruited with a ratio of 1:2. Besides univariable analysis, multivariable logistic regression was built to evaluate the potential risk factors. A total of 150 children was included with 50 in the case group and 100 in the control group. Median developing time from ITP to SLE was 34.5 [IQR 12.5, 58.75] months. ANA was found significantly different between the two groups in our study in the univariable analysis but not in the multivariable analysis (OR = 4.50, 95% CI 0.97 to 21.01). Age diagnosed ITP was positively associated with SLE (OR = 1.07 every 5 years, 95% CI 1.01 to 1.15) with alert point at 8 years old (sensitivity 0.82, specificity 0.60). A lower level of complement was also positively associated with SLE (OR = 8.33, 95% CI 1.62 to 42.91). A minimum 3-year of close follow-up for pediatric ITP patients was recommended to monitor the risk for developing SLE. Older age and hypocomplementemia were potential risk factors for the development from ITP to SLE.

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Authors and Affiliations

  1. Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 ShuaiFuYuan Street, Dongcheng District, Beijing, 100730, China

    Yuqing Song, Zhuo Li, Jing Liu, Juan Xiao & Hongmei Song

  2. Central Research Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

    Yuelun Zhang

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  1. Yuqing Song
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Contributions

All authors contributed to the study conception and design. Yuqing Song and Yuelun Zhang contributed equally to the article. Material preparation and data collection were performed by Yuqing Song and Jing Liu. Data analysis were performed by Yuqing Song and Yuelun Zhang. The first draft of the manuscript was written by Yuqing Song and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Juan Xiao or Hongmei Song.

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Cite this article

Song, Y., Zhang, Y., Li, Z. et al. Potential risk factors for the development from immune thrombocytopenia to systemic lupus erythematosus: a case–control study in Chinese children. Ann Hematol 101, 1447–1456 (2022). https://doi.org/10.1007/s00277-022-04836-5

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  • DOI: https://doi.org/10.1007/s00277-022-04836-5

Keywords

  • Immune thrombocytopenia
  • Systemic lupus erythematosus
  • Antinuclear antibody
  • Complement
  • Children