References
Garcia-Manero G, Chien KS, Montalban-Bravo G (2020) Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management. Am J Hematol 95(11):1399–1420. https://doi.org/10.1002/ajh.25950
Kroger N (2019) Induction, bridging, or straight ahead: the ongoing dilemma of allografting in advanced myelodysplastic syndrome. Biol Blood Marrow Transplant 25(8):e247–e249. https://doi.org/10.1016/j.bbmt.2019.06.016
Schroeder T, Wegener N, Lauseker M, Rautenberg C, Nachtkamp K, Schuler E, Kondakci M, Haas R, Germing U, Kobbe G (2019) Comparison between upfront transplantation and different pretransplant cytoreductive treatment approaches in patients with high-risk myelodysplastic syndrome and secondary acute myelogenous leukemia. Biol Blood Marrow Transplant 25(8):1550–1559. https://doi.org/10.1016/j.bbmt.2019.03.011
Sun YQ, Xu LP, Liu KY, Zhang XH, Yan CH, Jin J, Huang XJ, Wang Y (2021) Pre-transplantation cytoreduction does not benefit advanced myelodysplastic syndrome patients after myeloablative transplantation with grafts from family donors. Cancer Commun (Lond) 41(4):333–344. https://doi.org/10.1002/cac2.12140
Ye L, Ren Y, Zhou X, Mei C, Ma L, Ye X, Wei J, Xu W, Meng H, Qian W, Mai W, Lou Y, Xu G, Qian J, Lou Y, Luo Y, Xie L, Lin P, Hu C, Jin J, Tong H (2017) Decitabine priming prior to low-dose chemotherapy improves patient outcomes in myelodysplastic syndromes-RAEB: a retrospective analysis vs. chemotherapy alone. J Cancer Res Clin Oncol 143(5):873–882. https://doi.org/10.1007/s00432-016-2331-0
Meng T, Qi J, Zhu Y, Xu Y, Chen F, Xue S, Miao M, Chen S, Han Y, Tang X, Qiu H, Sun A, Wu D, Wang Y (2021) Impact of disease status at allogeneic stem cell transplantation on adolescent and young adult patients with early T-cell precursor acute lymphoblastic leukemia. Hematol Oncol 39(3):358–363. https://doi.org/10.1002/hon.2841
Cheson BD, Greenberg PL, Bennett JM, Lowenberg B, Wijermans PW, Nimer SD, Pinto A, Beran M, de Witte TM, Stone RM, Mittelman M, Sanz GF, Gore SD, Schiffer CA, Kantarjian H (2006) Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood 108(2):419–425. https://doi.org/10.1182/blood-2005-10-4149
Yoshida Y, Oguma S, Ohno H (2009) John Auer and Auer rods; controversies revisited. Leuk Res 33(5):614–616. https://doi.org/10.1016/j.leukres.2008.09.014
Schuler E, Zadrozny N, Blum S, Schroeder T, Strupp C, Hildebrandt B, Kundgen A, Gattermann N, Aul C, Kondakci M, Kobbe G, Haas R, Germing U (2018) Long-term outcome of high risk patients with myelodysplastic syndromes or secondary acute myeloid leukemia receiving intensive chemotherapy. Ann Hematol 97(12):2325–2332. https://doi.org/10.1007/s00277-018-3466-7
Huang H, Qin T, Xu Z, Shi Z, Li B, Pan L, Hu N, Qu S, Huang G, Gale RP, Xiao Z (2020) Mutational features of myelodysplastic syndromes with Auer rods reveal them are more akin to acute myeloid leukemia. Br J Haematol 188(5):796–800. https://doi.org/10.1111/bjh.16326
Germing U, Strupp C, Kuendgen A, Aivado M, Giagounidis A, Hildebrandt B, Aul C, Haas R, Gattermann N (2006) Refractory anaemia with excess of blasts (RAEB): analysis of reclassification according to the WHO proposals. Br J Haematol 132(2):162–167. https://doi.org/10.1111/j.1365-2141.2005.05853.x
Della Porta MG, Galli A, Bacigalupo A, Zibellini S, Bernardi M, Rizzo E, Allione B, van Lint MT, Pioltelli P, Marenco P, Bosi A, Voso MT, Sica S, Cuzzola M, Angelucci E, Rossi M, Ubezio M, Malovini A, Limongelli I, Ferretti VV, Spinelli O, Tresoldi C, Pozzi S, Luchetti S, Pezzetti L, Catricala S, Milanesi C, Riva A, Bruno B, Ciceri F, Bonifazi F, Bellazzi R, Papaemmanuil E, Santoro A, Alessandrino EP, Rambaldi A, Cazzola M (2016) Clinical effects of driver somatic mutations on the outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem-cell transplantation. J Clin Oncol 34(30):3627–3637. https://doi.org/10.1200/JCO.2016.67.3616
Lindsley RC, Saber W, Mar BG, Redd R, Wang T, Haagenson MD, Grauman PV, Hu ZH, Spellman SR, Lee SJ, Verneris MR, Hsu K, Fleischhauer K, Cutler C, Antin JH, Neuberg D, Ebert BL (2017) Prognostic mutations in myelodysplastic syndrome after stem-cell transplantation. N Engl J Med 376(6):536–547. https://doi.org/10.1056/NEJMoa1611604
Willis MS, McKenna RW, Peterson LC, Coad JE, Kroft SH (2005) Low blast count myeloid disorders with Auer rods: a clinicopathologic analysis of 9 cases. Am J Clin Pathol 124(2):191–198. https://doi.org/10.1309/WB79-MFV6-FCDJ-H2EG
Funding
This work was supported by grants from the National Natural Science Foundation of China (81,730,003, 81,870,120, 81,670,164), the Natural Science Foundation of Jiangsu Province (BK20171205), the Social Development Project of Jiangsu Province (BE2019655), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and the National Key Research and Development Program (2017ZX09304021, 2017YFA0104500, 2019YFC0840604). All the samples were from Jiangsu Biobank of Clinical Resources.
Author information
Authors and Affiliations
Contributions
Yi Wang designed and performed the research study, analyzed the data, and wrote the manuscript. Yaoyao Shen and Jiaqian Qi completed the research study and analyzed the data. Jia Chen, Yang Xu, Feng Chen, Xiao Ma, Miao Miao, and Shengli Xue contributed to the data analysis and manuscript writing. Huiying Qiu, Xiaowen Tang, Yue Han, Suning Chen, Aining Sun, and Yanming Zhang contributed to the external validation. Ying Wang and Depei Wu contributed to the research design, data analysis, writing the manuscript, and supervision of the study.
Corresponding authors
Ethics declarations
Ethics approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included.
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Yi Wang, Yaoyao Shen, and Jiaqian Qi are co-first authors
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Wang, Y., Shen, Y., Qi, J. et al. Prognostic impact of Auer rods for cytoreductive chemotherapy and myeloablative allogeneic stem cell transplantation in adult patients with myelodysplastic syndrome with excess blasts-2. Ann Hematol 101, 1611–1615 (2022). https://doi.org/10.1007/s00277-022-04808-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00277-022-04808-9