References
Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O’Brien S, Robak T, Seymour JF, Kipps TJ (2018) iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood 131(25):2745–2760
Giné E, Martinez A, Villamor N, López-Guillermo A, Camos M, Martinez D, Esteve J, Calvo X, Muntañola A, Abrisqueta P, Rozman M, Rozman C, Bosch F, Campo E, Montserrat E (2010) Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia (“accelerated” chronic lymphocytic leukemia) with aggressive clinical behavior. Haematologica 95(9):1526–1533
Robak E, Robak T (2007) Skin lesions in chronic lymphocytic leukemia. Leuk Lymphoma 48:855–865
Cerroni L, Zenahlik P, Höfler G, Kaddu S, Smolle J, Kerl H (1996) Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia: a clinicopathologicand prognostic study of 42 patients. Am J Surg Pathol 20(8):1000–1010
Aldapt MB, Yassin M (2021) Leukemia cutis as an early presentation or relapsing manifestation of chronic lymphocytic leukemia (CLL). Acta Biomed 92(2):e2021192
Albano D, Luca Camoni L, Rodella C, Giubbini R, Bertagna F (2020) 12-[18F]-FDG PET/CT role in detecting richter transformation of chronic lymphocytic leukemia and predicting overall survival. Clin Lymphoma Myeloma Leuk 21(3):e277-283
Agbay RL, Jain N, Loghavi S, Medeiros LJ, Khoury JD (2016) Histologic transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma. Am J Hematol 91(10):1036–1043
Asplund SL, McKenna RW, Howard MS, Kroft SH (2002) Immunophenotype does not correlate with lymph node histology in chronic lymphocytic leukemia/small lymphocytic lymphoma. Am J Surg Pathol 26(5):624–629
Ciccone M, Agostinelli C, Rigolin GM, Piccaluga PP, Cavazzini F, Righi S, Sista MT, Sofritti O, Rizzotto L, Sabattini E, Fioritoni G, Falorio S, Stelitano C, Olivieri A, Attolico I, Brugiatelli M, Zinzani PL, Saccenti E, Capello D, Negrini M, Cuneo A, Pileri S (2012) Proliferation centers in chronic lymphocytic leukemia: correlation with cytogenetic and clinicobiological features in consecutive patients analyzed on tissue microarrays. Leukemia 26(3):499–508
Colburn DE, Welch MA, Giles FJ (2002) Skin infiltration with chronic lymphocytic leukemia is consistent with a good prognosis. Hematology 7(3):187–188
Acknowledgements
We thank Edward Lowczowski from the Medical University of Lodz for editorial assistance and Aleksandra Samulska for technical assistance. We also thank Dr Ewa Wawrzyniak for performing genetic analysis and Maciej Naze MD, PhD, for providing PET/CT images. We are grateful to the medical, nursing, and laboratory staff of the participating departments for their contributions to this study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethics approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Consent to participate
Informed consent was obtained from the patient included in the study.
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Robak, E., Jesionek-Kupnicka, D., Stelmach, P. et al. Leukemia cutis in accelerated chronic lymphocytic leukemia: successful treatment with venetoclax and rituximab. Ann Hematol 101, 1387–1392 (2022). https://doi.org/10.1007/s00277-022-04753-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00277-022-04753-7