Skip to main content

Advertisement

SpringerLink
Log in

Achievement of rapid complete remission in an 87-year-old female patient with azacytidine-venetoclax for blastic plasmacytoid dendritic cell neoplasm

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Garnache-Ottou F, Feuillard J, Ferrand C, Biichle S, Trimoreau F, Seilles E et al (2009) Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia. Br J Haematol 145(5):624–636

    Article  CAS  Google Scholar 

  2. Garnache-Ottou F, Vidal C, Biichlé S, Renosi F, Poret E, Pagadoy M et al (2019) How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients? Blood Adv 3(24):4238–4251

    Article  CAS  Google Scholar 

  3. Laribi K, Denizon N, Ghnaya H, Atlassi M, Besançon A, Pineau-Vincent F et al (2014) Blastic plasmacytoid dendritic cell neoplasm: the first report of two cases treated by 5-azacytidine. Eur J Haematol 93(1):81–85

    Article  CAS  Google Scholar 

  4. Agha ME, Monaghan SA, Swerdlow SH (2018) Venetoclax in a patient with a blastic plasmacytoid dendritic-cell neoplasm. N Engl J Med 379(15):1479–1481

    Article  Google Scholar 

  5. Sapienza MR, Fuligni F, Agostinelli C, Tripodo C, Righi S, Laginestra MA et al (2014) Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to NF-kB pathway inhibition. Leukemia 28(8):1606–1616

    Article  CAS  Google Scholar 

  6. DiNardo CD, Rausch CR, Benton C, Kadia T, Jain N, Pemmaraju N et al (2018) Clinical experience with the BCL2-inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies. Am J Hematol 93(3):401–407

    Article  CAS  Google Scholar 

  7. DiNardo CD, Pratz K, Pullarkat V, Jonas BA, Arellano M, Becker PS et al (2019) Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia. Blood 133(1):7–17

    Article  CAS  Google Scholar 

  8. DiNardo CD, Jonas BA, Pullarkat V, Thirman MJ, Garcia JS, Wei AH et al (2020) Azacitidine and venetoclax in previously untreated acute myeloid leukemia. N Engl J Med 383(7):617–629

    Article  CAS  Google Scholar 

  9. Sapienza MR, Abate F, Melle F, Orecchioni S, Fuligni F, Etebari M et al (2019) Blastic plasmacytoid dendritic cell neoplasm: genomics mark epigenetic dysregulation as a primary therapeutic target. Haematologica 104(4):729–737

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service d’hématologie, Centre Hospitalier Intercommunal (CHIC) Quimper Cornouaille, Quimper, France

    Ronan Le Calloch, Lenaïg Le Clech & Pascal Hutin

  2. Fédération Inter Hospitalière d’Hématologie de Bretagne Occidentale (FIHBO), Brest, France

    Ronan Le Calloch, Lenaïg Le Clech, Pascal Hutin & Jean Christophe Ianotto

  3. Laboratoire de Biologie Médicale, Centre Hospitalier Intercommunal (CHIC) Quimper Cornouaille, Quimper, France

    Bertrand Arnaud

  4. Centre Georges Charpak - Médecine Nucléaire–TEP Cornouaille-Quimper, Quimper, France

    François Salmon

  5. Inserm UMR1098, Université de Franche-Comté, Besançon, France

    Francine Garnache Ottou

  6. Laboratoire Hématologie, Etablissement Français du Sang Bourgogne Franche-Comté, Besançon, France

    Francine Garnache Ottou

  7. Service d’hématologie, Centre Hospitalier Régional Universitaire (CHRU) Brest, Brest, France

    Jean Christophe Ianotto

  8. Service d’hématologie, Centre Hospitalier Le Mans, Le Mans, France

    Kamel Laribi

Authors
  1. Ronan Le Calloch
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bertrand Arnaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lenaïg Le Clech
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pascal Hutin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. François Salmon
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Francine Garnache Ottou
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jean Christophe Ianotto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Kamel Laribi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ronan Le Calloch.

Ethics declarations

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent was obtained from the patient for being included in the study.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Le Calloch, R., Arnaud, B., Le Clech, L. et al. Achievement of rapid complete remission in an 87-year-old female patient with azacytidine-venetoclax for blastic plasmacytoid dendritic cell neoplasm. Ann Hematol 101, 1347–1349 (2022). https://doi.org/10.1007/s00277-021-04718-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-021-04718-2

Search

Navigation