Data availability
The data of this case report are available from the corresponding author, Shinya Yamada, upon reasonable request.
Code availability
Not applicable.
References
Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127(20):2391–2405. https://doi.org/10.1182/blood-2016-03-643544
Grigano E, Jachiet V, Fenaux P, Ades L, Fain O, Mekinian A (2018) Autoimmune manifestations associated with myelodysplastic syndromes. Ann Hematol 97(11):2015–2023. https://doi.org/10.1007/s00277-018-3472-9
Jäger U, Barcellini W, Broome CM (2020) Diagnosis and treatment of autoimmune hemolytic anemia in adults: recommendations from the First International Consensus Meeting. Blood Rev 41:100648. https://doi.org/10.1016/j.blre.2019.100648
Cheson BD, Greenberg PL, Bennett JM, Lowenberg B, Wijermans PW, Nimer SD, Pinto A, Beran M, de Witte TM, Stone RM, Mittelman M, Sanz GF, Gore SD, Schiffer CA, Kantarjian H (2006) Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood 108(2):419–425. https://doi.org/10.1182/blood-2005-10-4149
Pilorge S, Doleris LM, Dreyfus F, Park S (2011) The autoimmune manifestations associated with myelodysplastic syndrome respond to 5-azacytidine: a report on three cases. Br J Haematol 153(5):664–665. https://doi.org/10.1111/j.1365-2141.2010.08557.x
Tanaka H, Shimizu N, Tougasaki E, Kawajiri C, Hashimoto S, Takeda Y, Sakai S, Takeuchi M, Ohwada C, Sakaida E, Takagi T, Nakaseko C (2013) Successful treatment by azacitidine therapy of intestinal Behçet’s disease associated with myelodysplastic syndrome. Int J Hematol 97(4):520–524. https://doi.org/10.1007/s12185-013-1316-x
Lin JT, Wang WS, Yen CC, Chiou TJ, Liu JH, Hsiao LT, Yang MH, Chao TC, Tai CJ, Chen PM (2002) Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. Ann Hematol 81(12):723–726. https://doi.org/10.1007/s00277-002-0539-3
Oren H, Uçar C, Gülen H, Duman M, Irken G (2001) Autoimmune hemolytic anemia occurring with myelodysplastic syndrome: report of a pediatric case and review of literature. Ann Hematol 80(9):540–542. https://doi.org/10.1007/s002770100332
Kaur J, Tuler S, Dasanu CA (2021) Autoimmune hemolytic anemia in a patient with myelodysplastic syndrome: responding to 5-azacitidine therapy. J Oncol Pharm Pract. https://doi.org/10.1177/1078155220987616
Okada M, Okamoto T, Takemoto Y, Kanamaru A, Kakishita E (2000) Function and X chromosome inactivation analysis of B lymphocytes in myelodysplastic syndromes with immunological abnormalities. Acta Haematol 102(3):124–130. https://doi.org/10.1159/000040985
Author information
Authors and Affiliations
Contributions
Shinya Yamada and Sayaka Kajikawa were attending physicians. Hirokazu Okumura was a medical advisor. Noriharu Nakagawa and Yukio Kondo made suggestions about writing this letter.
Corresponding author
Ethics declarations
Ethics approval
Informed consent was obtained from the patient.
Consent to participate
Informed consent was obtained from the patient.
Consent for publication
Informed consent was obtained from the patient.
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher's note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Yamada, S., Kajikawa, S., Nakagawa, N. et al. Coombs’ test positive autoimmune hemolytic anemia accompanied by myelodysplastic syndrome that became Coombs’ test negative after azacitidine administration. Ann Hematol 101, 915–917 (2022). https://doi.org/10.1007/s00277-021-04652-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00277-021-04652-3