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A novel case of γδ T cell leukemia with recurrent genetic abnormalities accompanied by agranulocytosis

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References

  1. Swerdlow S, Campo E, Harris N, Jaffe E, Pileri S, Stein H (2016) WHO classification of tumours of haematopoietic and lymphoid tissues, Lyon. IARC Press

  2. Teramo A, Barila G, Calabretto G, Ercolin C, Lamy T, Moignet A, Roussel M, Pastoret C, Leoncin M, Gattazzo C, Cabrelle A, Boscaro E, Teolato S, Pagnin E, Berno T, De March E, Facco M, Piazza F, Trentin L, Semenzato G, Zambello R (2017) STAT3 mutation impacts biological and clinical features of T-LGL leukemia. Oncotarget 8(37):61876–61889

    Article  Google Scholar 

  3. Matos DM, Rizzatti EG, Fernandes M, Buccheri V, Falcao RP (2005) Gammadelta and alphabeta T-cell acute lymphoblastic leukemia: comparison of their clinical and immunophenotypic features. Haematologica 90(2):264–266

    PubMed  Google Scholar 

  4. Kaleem Z, Crawford E, Pathan MH, Jasper L, Covinsky MA, Johnson LR, White G (2003) Flow cytometric analysis of acute leukemias - diagnostic utility and critical analysis of data. Arch Pathol Lab Med 127(1):42–48

    Article  Google Scholar 

  5. Zhou Y, Fan XS, Routbort M, Yin CC, Singh R, Bueso-Ramos C, Thomas DA, Milton DR, Medeiros LJ, Lin P (2013) Absence of terminal deoxynucleotidyl transferase expression identifies a subset of high-risk adult T-lymphoblastic leukemia/lymphoma. Modern Pathol 26(10):1338–1345

    Article  CAS  Google Scholar 

  6. Muntean AG, Hess JL (2012) The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol 7:283–301

    Article  CAS  Google Scholar 

  7. Meyer C, Burmeister T, Groger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-de-Oliveira MS, Barbieri Blunck C, Almeida Lopes B, Zuna J, Trka J, Ballerini P, Lapillonne H, De Braekeleer M, Cazzaniga G, Corral Abascal L, van der Velden VHJ, Delabesse E, Park TS, Oh SH, Silva MLM, Lund-Aho T, Juvonen V, Moore AS, Heidenreich O, Vormoor J, Zerkalenkova E, Olshanskaya Y, Bueno C, Menendez P, Teigler-Schlegel A, Zur Stadt U, Lentes J, Gohring G, Kustanovich A, Aleinikova O, Schafer BW, Kubetzko S, Madsen HO, Gruhn B, Duarte X, Gameiro P, Lippert E, Bidet A, Cayuela JM, Clappier E, Alonso CN, Zwaan CM, van den Heuvel-Eibrink MM, Izraeli S, Trakhtenbrot L, Archer P, Hancock J, Moricke A, Alten J, Schrappe M, Stanulla M, Strehl S, Attarbaschi A, Dworzak M, Haas OA, Panzer-Grumayer R, Sedek L, Szczepanski T, Caye A, Suarez L, Cave H, Marschalek R (2018) The MLL recombinome of acute leukemias in 2017. Leukemia 32(2):273–284

    Article  CAS  Google Scholar 

  8. Turkmen S, Timmermann B, Bartels G, Groger D, Meyer C, Schwartz S, Haferlach C, Rieder H, Gokbuget N, Hoelzer D, Marschalek R, Burmeister T (2012) Involvement of the MLL gene in adult T-lymphoblastic leukemia. Genes Chromosomes Cancer 51(12):1114–1124

    Article  Google Scholar 

  9. Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT (2011) The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood 118(15):4169–4173

    Article  CAS  Google Scholar 

  10. Kominami R (2012) Role of the transcription factor Bcl11b in development and lymphomagenesis. Proc Jpn Acad Ser B Phys Biol Sci 88(3):72–87

    Article  CAS  Google Scholar 

  11. Andersson EI, Rajala HL, Eldfors S, Ellonen P, Olson T, Jerez A, Clemente MJ, Kallioniemi O, Porkka K, Heckman C, Loughran TP Jr, Maciejewski JP, Mustjoki S (2013) Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation. Blood Cancer J 3:e168

    Article  CAS  Google Scholar 

  12. Yamamoto-Sugitani M, Kuroda J, Shimura Y, Nagoshi H, Chinen Y, Ohshiro M, Mizutani S, Kiyota M, Nakayama R, Kobayashi T, Uchiyama H, Matsumoto Y, Horiike S, Taniwaki M (2012) Comprehensive cytogenetic study of primary cutaneous gamma-delta T-cell lymphoma by means of spectral karyotyping and genome-wide single nucleotide polymorphism array. Cancer Genet 205(9):459–464

    Article  CAS  Google Scholar 

  13. Tamai H, Inokuchi K (2010) 11q23/MLL acute leukemia : update of clinical aspects. J Clin Exp Hematop 50(2):91–98

    Article  Google Scholar 

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Acknowledgments

We thank Ms. Chie Suzuki (Department of Laboratory, Tohoku University Hospital) for providing excellent technical support.

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Authors and Affiliations

  1. Department of Hematology, Tohoku University Hospital, 1-1 Seiryo-cho, Sendai, 980-8574, Japan

    Satoshi Ichikawa, Tohru Fujiwara, Kei Saito, Noriko Fukuhara, Hisayuki Yokoyama, Shunsuke Hatta, Koichi Onodera, Yasushi Onishi & Hideo Harigae

  2. Department of Hematology, National Hospital Organization Sendai Medical Center, Sendai, Japan

    Kei Saito & Shunsuke Hatta

  3. Department of Pathology, Tohoku University Hospital, Sendai, Japan

    Fumiyoshi Fujishima

  4. Department of Hematopathology, Tohoku University Hospital, Sendai, Japan

    Ryo Ichinohasama

Authors
  1. Satoshi Ichikawa
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  2. Tohru Fujiwara
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  3. Kei Saito
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  4. Noriko Fukuhara
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  5. Hisayuki Yokoyama
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  6. Shunsuke Hatta
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  7. Koichi Onodera
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  8. Yasushi Onishi
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  9. Fumiyoshi Fujishima
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  11. Hideo Harigae
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Corresponding author

Correspondence to Satoshi Ichikawa.

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Conflict of interest

The authors declare that they have no conflict of interest. They all approved the final manuscript. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975 and its later amendments. Informed consent was obtained from the patient for being included in the study.

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Ichikawa, S., Fujiwara, T., Saito, K. et al. A novel case of γδ T cell leukemia with recurrent genetic abnormalities accompanied by agranulocytosis. Ann Hematol 100, 2665–2668 (2021). https://doi.org/10.1007/s00277-020-04241-w

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  • DOI: https://doi.org/10.1007/s00277-020-04241-w

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