Skip to main content

Advertisement

Log in

CD30 expression: a diagnostic pitfall for primary cutaneous gamma delta T cell lymphoma

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

References

  1. Leventaki V, Bhattacharyya S, Lim MS (2020) Pathology and genetics of anaplastic large cell lymphoma. Semin Diagn Pathol 37(1):57–71

    Article  Google Scholar 

  2. Kempf W (2017) A new era for cutaneous CD30-positive T-cell lymphoproliferative disorders. Semin Diagn Pathol 34(1):22–35

    Article  Google Scholar 

  3. Rodríguez-Pinilla SM, Ortiz-Romero PL, Monsalvez V, Tomás IE, Almagro M, Sevilla A, Camacho G, Longo MI, Pulpillo Á, Diaz-Pérez JA, Montes-Moreno S, Castro Y, Echevarría B, Trébol I, Gonzalez C, Sánchez L, Otín AP, Requena L, Rodríguez-Peralto JL, Cerroni L, Piris MÁ (2013) TCR-γ expression in primary cutaneous T-cell lymphomas. Am J Surg Pathol 37(3):375–384

    Article  Google Scholar 

  4. Pulitzer M, Geller S, Kumar E, Frosina D, Moskowitz A, Horwitz S, Myskowski P, Kheterpal M, Chan A, Dogan A, Jungbluth A (2018) T-cell receptor-δ expression and γδ+ T-cell infiltrates in primary cutaneous γδ T-cell lymphoma and other cutaneous T-cell lymphoproliferative disorders. Histopathology 73(4):653–662

    Article  Google Scholar 

  5. Bonzheim I, Geissinger E, Roth S, Zettl A, Marx A, Rosenwald A, Müller-Hermelink HK, Rüdiger T (2004) Anaplastic large cell lymphomas lack the expression of T-cell receptor molecules or molecules of proximal T-cell receptor signaling. Blood 104(10):3358–3360

    Article  CAS  Google Scholar 

  6. Geissinger E, Sadler P, Roth S, Grieb T, Puppe B, Müller N, Reimer P, Vetter-Kauczok CS, Wenzel J, Bonzheim I, Rüdiger T, Müller-Hermelink HK, Rosenwald A (2010) Disturbed expression of the T-cell receptor/CD3 complex and associated signaling molecules in CD30+ T-cell lymphoproliferations. Haematologica 95(10):1697–1704

    Article  CAS  Google Scholar 

  7. Jaffe ES, Paulli M, Kadin ME (2017) Primary cutaneous CD30-positive T-cell lymphoroliferative disorders. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (eds) WHO classification of tumours of haematopoietic and lymphoid tissues. International Agency for Research on Cancer, Lyon, pp 392–396

    Google Scholar 

  8. Suzuki R, Kagami Y, Takeuchi K, Kami M, Okamoto M, Ichinohasama R, Mori N, Kojima M, Yoshino T, Yamabe H, Shiota M, Mori S, Ogura M, Hamajima N, Seto M, Suchi T, Morishima Y, Nakamura S (2000) Prognostic significance of CD56 expression for ALK-positive and ALK-negative anaplastic large-cell lymphoma of T/null cell phenotype. Blood 96(9):2993–3000

    CAS  PubMed  Google Scholar 

  9. Jaffe ES, Gaulard P, Cerroni L (2017) Subcutaneous panniculitis-like T-cell lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (eds) WHO classification of tumours of haematopoietic and lymphoid tissues. International Agency for Research on Cancer, Lyon, pp 383–385

    Google Scholar 

  10. Salhany KE, Macon WR, Choi JK, Elenitsas R, Lessin SR, Felgar RE, Wilson DM, Przybylski GK, Lister J, Wasik MA, Swerdlow SH (1998) Subcutaneous panniculitis-like T-cell lymphoma: clinicopathologic, immunophenotypic, and genotypic analysis of alpha/beta and gamma/delta subtypes. Am J Surg Pathol 22(7):881–893

    Article  CAS  Google Scholar 

  11. Vin H, Talpur R, Tetzlaff MT, Duvic M (2014) T-cell receptor-γ in gamma-delta phenotype cutaneous T-cell lymphoma can be accompanied by atypical expression of CD30, CD4, or TCRβF1 and an indolent clinical course. Clin Lymphoma Myeloma Leuk 14(6):e195–e200

    Article  Google Scholar 

  12. Merrill ED, Agbay R, Miranda RN, Aung PP, Tetzlaff MT, Young KH, Curry JL, Nagarajan P, Ivan D, Prieto VG, Medeiros LJ, Duvic M, Torres-Cabala CA (2017) Primary cutaneous T-cell lymphomas showing gamma-delta (γδ) phenotype and predominantly epidermotropic pattern are clinicopathologically distinct from classic primary cutaneous γδ T-cell lymphomas. Am J Surg Pathol 41(2):204–215

    Article  Google Scholar 

  13. Gammon B, Gammon BR, Kim YH, Kim J (2016) Neurotropic gamma-delta T-cell lymphoma with CD30-positive lymphoid infiltrates. Am J Dermatopathol 38(9):e133–e136

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

Karen Tang: patient treatment, manuscript writing, and approval. Rex Au-Yeung: histopathological diagnosis, manuscript writing, and approval. Shun-Hin Ting: histopathological diagnosis, manuscript writing, and approval. Yok-Lam Kwong: patient treatment, manuscript writing, and approval.

Corresponding author

Correspondence to Yok-lam Kwong.

Ethics declarations

Conflict of interest

The authors declare that they have no conflicts of interest.

Informed consent

The patient gave informed consent to treatment.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tang, K.H.K., Au-Yeung, R., Ting, SH. et al. CD30 expression: a diagnostic pitfall for primary cutaneous gamma delta T cell lymphoma. Ann Hematol 100, 2653–2657 (2021). https://doi.org/10.1007/s00277-020-04229-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-020-04229-6

Navigation