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Clinical characteristics and outcomes of primary adrenal diffuse large B cell lymphoma in a large contemporary cohort: a SEER-based analysis

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Abstract

Primary adrenal lymphoma (PAL) is an extremely rare lymphoma, and the most common histologic type is diffuse large B cell lymphoma (DLBCL). Primary adrenal DLBCL has a quite poor prognosis, but the prognostic determinants are rarely reported. With the Surveillance, Epidemiology, and End Results (SEER) program, we collected the demographic, clinical, therapeutic information of patients with primary adrenal DLBCL from 1983 to 2015. The Kaplan-Meier method was used to obtain overall survival (OS) and cause-specific survival (CSS) curves. The prognostic values of OS and CSS were assessed using Cox proportional hazards regression model with univariate and multivariate analyses. A total of 136 patients were included in our cohort. Adrenal DLBCL predominantly affected male and the aged, and there was a high rate of unilateral adrenal origin. The patients were more likely to present advanced stage disease. The OS rates of the entire cohort of patients with adrenal DLBCL at 5 and 10 years were respectively 19.17% and 3.33%, and the similar results were shown in 5-year and 10-year CSS rates. Age more than 70 years old and bilateral were identified as independent prognostic factors that were correlated with both adverse OS and CSS, and patients with chemotherapy had a superior OS and CSS to the patients without any treatment.

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Funding

This study was supported by the National Natural Science Foundation of China (no. 81572920), Natural Science Foundation of Zhejiang Province of China (no. LY15H160038), and National Basic Research Program of China (no. 2013CB911303).

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Author notes

  1. Shu Li and Zhan Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Hematology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China

    Shu Li, Zhaoxing Wu & Yang Xu

  2. Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China

    Shu Li & Zhaoxing Wu

  3. Center for Orthopaedic Research, Orthopaedics Research Institute of Zhejiang University, Department of Orthopaedics, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China

    Zhan Wang

  4. Department of Hematology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310009, China

    Haifeng Zhuang

Authors
  1. Shu Li
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Correspondence to Yang Xu.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Supplemental Figure 1

OS Kaplan–Meier Curves of patients with primary adrenal DLBCL divided by gender, race, year of diagnosis and stage. (PNG 184 kb)

High resolution image (TIF 1331 kb)

Supplemental Figure 2

CSS Kaplan–Meier Curves of patients with primary adrenal DLBCL divided by gender, race, year of diagnosis and stage. (PNG 202 kb)

High resolution image (TIF 1336 kb)

Supplemental Table 1

(DOCX 14 kb)

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Li, S., Wang, Z., Wu, Z. et al. Clinical characteristics and outcomes of primary adrenal diffuse large B cell lymphoma in a large contemporary cohort: a SEER-based analysis. Ann Hematol 98, 2111–2119 (2019). https://doi.org/10.1007/s00277-019-03740-9

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  • DOI: https://doi.org/10.1007/s00277-019-03740-9

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