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Ruxolitinib therapy is associated with improved renal function in patients with primary myelofibrosis

Abstract

Recent evidence suggests that renal dysfunction may be a direct consequence of primary myelofibrosis (PMF). We performed a retrospective analysis of 100 patients with previously untreated PMF, receiving frontline treatment with single agent ruxolitinib, and compared them to 105 patients, receiving frontline treatment with a non-ruxolitinib-based therapy, matched by age, sex, DIPSS plus, and estimated glomerular filtration rate (eGFR). Use of ruxolitinib associated with a significantly higher rate of renal improvement (RI) > 10% (73% vs 50%, p = 0.01) confirmed on multivariate analysis (MVA) [odds ratio 3, 95% confidence interval (CI) 1.6–5.5, p < 0.001]. After a median follow-up of 41 months (range, 1–159 months), median failure-free survival (FFS) was 14 months (range, 1–117 months). Achievement of a RI > 10% maintained its independent association with prolonged FFS on MVA (hazard ratio 1.4, 95% CI 1.1–2, p = 0.02). Ruxolitinib can significantly improve renal function in patients with PMF, significantly impacting failure-free survival.

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Authors

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PS designed the study, analyzed data, and wrote the paper; SV provided clinical care to patients and coauthored the paper; MA and US provided clinical care to patients and coauthored the paper; VDP and SAP collected clinical data and coauthored the paper; AA designed the study, analyzed the data, provided clinical care to patients, and wrote the paper.

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Correspondence to Srdan Verstovsek or Ala Abudayyeh.

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Strati, P., Abdelrahim, M., Selamet, U. et al. Ruxolitinib therapy is associated with improved renal function in patients with primary myelofibrosis. Ann Hematol 98, 1611–1616 (2019). https://doi.org/10.1007/s00277-019-03708-9

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  • DOI: https://doi.org/10.1007/s00277-019-03708-9

Keywords

  • PMF
  • Ruxolitinib
  • Renal function